Search

… well. One is to do DNA sequencing. So upon sequencing many genomes, now we don’t have to, as in the past, go randomly … natural product producing organism, the Actinomyces, was completed in early 2000s. One of the major discovery from … Okay, great. Yeah. I mean, that’s important for community uptake. For sure.  DAN: I wanted to know a little bit about …

… conversation with Aaron Puri. He is an Assistant Professor from the Chemistry department at the University of Utah, so … in love with the bacteria part of that. And so I decided to completely change gears and go and do a postdoc with a woman … And it actually was jumping onto the I ntegrated Microbial Genomes and Metagenomes, the IMG platform that JGI has that …

… approaches to identify and characterize genomic information from uncultivated microbes and viruses. We develop … computational approaches to sift through thousands of metagenomes for signatures of viruses and novel microbial … and reconstruct metabolic properties encoded within those genomes. Our aim is to more fully capture microbial and …

… cell types and associated organisms, including fungal and bacterial symbionts, detrimental microbial pathogens, and … genomics-powered tools to study this complexity, including single-cell and spatial transcriptomics barcode-based … viruses. Resident viruses can be found in a myriad of bacterial strains, whereby they can modulate host …

… our interview this week is with Professor Brian Bachmann from Vanderbilt University’s Chemistry Department, where he … together a proper introductory episode with her in the near future where we can dive into that. And I’m also dying … called Ecopia was talking about a gene cluster a week. They completed a gene cluster per week. And that really got me …

… diversity of alternative genetic codes (Science 2014), unearthing hundreds of thousands of new viral genomes and their predicted hosts (Nature 2016, Science … Molecular Cell 2019) and massive reconstruction of genomes from uncultivated microbes (Nature 2019). Other projects in …

… While an ever-increasing number of phage and virus genomes have been assembled and reported from metagenomes, our understanding of the impacts of these viruses … in microbiomes, these omics data must be complemented with single-cell resolution assays that can be targeted towards …

… Program uses advanced sequencing technologies to decode the genomes of microbes in their natural environments. This work … catalog of viral, microbial, and microeukaryote genomes and mobile genetic elements, linked to custom … regulation, and noncoding RNAs in microbiomes. The insights from this work have the potential to drive innovations in …

… With a new methodology, scientists are now getting more complete genomic results from single cells. The Science Studying the  genomes of microorganisms is incredibly useful for … , a method called Primary Template-Directed Amplification (PTA) yields a much higher completion, above 80% in most …

… rights in technical data, project reporting to the DOE, and publication requirements. An official with authority is … and delays on the work. The transfer of a proposal from one commercial institution to a new commercial … that will be sent from JGI when their technical work is completed.  Having the MTA in place before work starts will …

… things very distal from them. So just because they're nearby doesn't necessarily mean they won't. They've been … with known receptors, but we also have ones that are completely their own cluster. And so we're hypothesizing … in is actually seeing whether we could go into the genomes and predict what the natural product might actually …

… for amplifying the JGI’s impact. Data generated from a single investment will be reused for further science.  … Download plant, algal, fungal and microbial genomes and metagenomes — top-quality genomic data, open to all researchers. … analysis and annotation of all publicly available genomes from three domains of life, in a uniquely integrated …