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… well. One is to do DNA sequencing. So upon sequencing many genomes, now we don’t have to, as in the past, go randomly … natural product producing organism, the Actinomyces, was completed in early 2000s. One of the major discovery from … Okay, great. Yeah. I mean, that’s important for community uptake. For sure.  DAN: I wanted to know a little bit about …

… in love with the bacteria part of that. And so I decided to completely change gears and go and do a postdoc with a woman … And it actually was jumping onto the I ntegrated Microbial Genomes and Metagenomes, the IMG platform that JGI has that … up on previous Natural Prodcast episodes  here . Show Notes Publication: Suo Z et al. A Mesorhizobium japonicum quorum …

… our interview this week is with Professor Brian Bachmann from Vanderbilt University’s Chemistry Department, where he … together a proper introductory episode with her in the near future where we can dive into that. And I’m also dying … called Ecopia was talking about a gene cluster a week. They completed a gene cluster per week. And that really got me …

… cell types and associated organisms, including fungal and bacterial symbionts, detrimental microbial pathogens, and … genomics-powered tools to study this complexity, including single-cell and spatial transcriptomics barcode-based … of plant/environmental responses … Selected Publications … Research Team Alumni … For further details, …

Program uses advanced sequencing technologies to decode the genomes of microbes in their natural environments. This work … assembly and binning have enabled reconstruction of complete or near-complete population genomes directly from the …

… diversity of alternative genetic codes (Science 2014), unearthing hundreds of thousands of new viral genomes and … Nayfach S, et al. (2021) CheckV assesses the quality and completeness of metagenome-assembled viral genomes. Nature … Science 344(6186):909-13 … Research Efforts … Selected Publications … For further details, please reach out to the …

… rights in technical data, project reporting to the DOE, and publication requirements. An official with authority is … and delays on the work. The transfer of a proposal from one commercial institution to a new commercial … that will be sent from JGI when their technical work is completed.  Having the MTA in place before work starts will …

With a new methodology, scientists are now getting more complete genomic results from single cells. The Science Studying the  genomes of microorganisms is incredibly useful for … , a method called Primary Template-Directed Amplification (PTA) yields a much higher completion, above 80% in most …

… interactions with their environments and with each other, from defending against predators to aiding in symbiotic … factors and determine their binding sites across multiple genomes. Computational prediction of heterologous … signatures of horizontal gene transfer. … The SMC provides complete sequence and annotation data for secondary …

… things very distal from them. So just because they're nearby doesn't necessarily mean they won't. They've been … with known receptors, but we also have ones that are completely their own cluster. And so we're hypothesizing … in is actually seeing whether we could go into the genomes and predict what the natural product might actually …

Laboratory. Being a User Facility means that scientists from all over the world bring us big problems related to … ALISON: Hmm. It kind of – it’s kind of like I’m smelling bacterial perfume. I mean – but it’s purposeful so it’s some … Taxol is also produced by a fungus that happens to grow near this tree and so there was probably some historical …

PIs or co-PIs) who wish to include use-restricted data in publications, or who wish to redistribute data in any way … span several years. Projects are defined at proposal acceptance and may also be added during the proposal lifecycle … based on scientific need. Proposals are considered complete when all agreed-upon projects are complete. This …