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… tiny algae. The cold polar oceans give rise to some of the largest food webs on Earth. And at their base are … webs are microscopic photosynthesizing organisms called phytoplankton (from the Greek phyto for ‘plant’ and planktos … in algal communities, including the algae-associated microbiomes that influence algal diversity and gene …

… for you here today. We got the opportunity to talk to one of the real legends of natural products, Professor Bill Fenical from Scripps Institution of Oceanography in San Diego. Bill … So, this was when we started saying, we have to have the genomes. We have to look at the full picture of these. And …

… DAN: You’re listening to the US Department of Energy Joint Genome Institute’s “Natural Prodcast,” a … Sequencing Program, and they worked with us to sequence two genomes. Those were of Salinospora tropica and arenicola . … the end of last year. Dan: So these are going to be seaweed metagenomes? You’re sequencing everything? Brad: Metagenomes …

… know that that’s ever necessarily like a good description of anyone because chemistry means a lot, especially when … And we’ve done some work with those and have a couple of publications out there on the chemistry. There’s so much … almost never Actinomycetes. And so when we look at their genomes we don’t get the same kind of information that we …

… DAN: You’re listening to the US Department of Energy Joint Genome Institute’s “Natural Prodcast,” a … week, we have our conversation with Professor Eric Schmidt, from the University of Utah. I’ve known Eric for a long time … the end, we took an approach that was kind of a simplified metagenome sequencing approach to pick this system apart.  …

… well-integrated across JGI departments to ensure a robust offering of sequencing capabilities and products to our users. This includes scaling the technologies and enabling state-of-the-art sample processing and sequencing capabilities. … profiling transcription factor binding sites across entire genomes. This technology has been further scaled to a …

… Research in the Woyke laboratory focuses on the utility of single-cell methods to access genetic material of uncultivated taxa of interest. One such effort is targeted at environmental cells that are from candidate phyla, major branches in the phylogenetic …

… DAN: Hey, everybody. Welcome back for another episode of Natural Prodcast. Right now I’m working on this the … And it actually was jumping onto the I ntegrated Microbial Genomes and Metagenomes, the IMG platform that JGI has that really got … up on previous Natural Prodcast episodes  here . Show Notes Publication: Suo Z et al. A Mesorhizobium japonicum quorum …

… and a tool for predicting natural product structures from genomes. And I was writing grants furiously to try to get … primer episode, we talked about genome mining through some metagenome associated genomes. And yes, antiSMASH is … especially if you want to know to which metagenome assembled genomes within a metagenome they belong and to …

… Micro-Scale Applications group explores the genetic makeup of natural microbial communities using a variety of cutting-edge approaches.  Our group also seeks out new … technology in order to enhance the quality of single-cell genomes and directly link functional information with …

… yes, sure, right. And yeah, so we worked on the Salinospora genomes. That was a really fun project. We had Brad on and … Usually, in a lot of cases, we still have to go through publications to get proteins, and their functions, and all … that easily can identify secondary metabolite pathways in metagenomes, which is still hard to do. We are mining a lot …