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… welcome, Nadine. ALISON TAKEMURA: What is the big picture for you in your lab? NADINE ZIEMERT: Big picture, I want to … seeing that. And I’m always just looking from the genes and pathways and what’s happening there. And he really saw this … Usually, in a lot of cases, we still have to go through publications to get proteins, and their functions, and all …

… DAN: Hello, everyone, and Welcome back for Episode 14 of Natural Prodcast . There’s been a lot … me really interested in microbial gene regulation and some pathways. And I thought I’d take an academic job then, but I … help the Society grow. And so I’ve been the chair of the publications committee for the last, what is it now, five …

… the exploration of secondary metabolites across bacteria, fungi, algae and plants. These molecules, which are not essential for fundamental growth, provide critical advantages to the organisms producing them, and are often involved in defense, nutrient … these hidden biochemical resources by exploring the genetic pathways responsible for their synthesis. The Secondary …

… DAN: You’re listening to the US Department of Energy Joint Genome Institute’s … Takemura, whose voice you’ll hear in a minute – we work for the US Department of Energy Joint Genome Institute, or … ALISON: Okay. We’re looking at a schematic of different pathways in a microbial cell, it looks like. It could be a …

… DAN: You’re listening to the US Department of Energy Joint Genome Institute’s … and SIO. Oh, I should say what those are. Brad: What’s SIO, for all those listeners out there? Dan: Scripps Institution … , but circular. 10% of the genome encoded natural product pathways. Dan: Yeah, that’s kind of a trend now. But at the …

… strengthens -omics technologies at the JGI by identifying the actual molecules present in an environment that … cycling, and leads to the discovery of new molecules and pathways. The JGI Metabolomics Platform delivers rich metabolite profiles from diverse … details on the instrumentation we use and our methodology for metabolite analyses.  …

… Dan Udwary: You’re listening to the Department of Energy Joint Genome Institute’s … identify and interpret biosynthetic, secondary metabolism pathways. And today, we get to present our conversation with … genome miners use, including antiSMASH, MIBiG, and newer efforts, like BiG-scape and BiG-SLiCE, and now the BiG-FAM …

… DAN: Hey, everybody. Welcome back for another episode of Natural Prodcast. Right now I’m working on this the afternoon of the day I’m due to release it, … before we even had access to genomes. How you identify the pathways? You would do for gene labeling. You would do you …

… and the bacteria and how the chemistry is going back and forth between them is part of what fascinates me about what … And we’ve done some work with those and have a couple of publications out there on the chemistry. There’s so much … And so then there isn’t horizontal transfer and so those pathways don’t have to be clustered so they end up probably …

… Every approved proposal starts with a User Agreement — before any work can begin, including the submission of samples for sequencing, or … rights in technical data, project reporting to the DOE, and publication requirements. An official with authority is … of the JGI User Agreement , JGI User Agreement for Federal Agencies , DNA Synthesis Appendix  and DNA …

… back to a new session of Natural Prodcast. I’ve got two things I wanted to tell you about in this introduction. First and foremost, our interview this week is with Professor Brian … mining company, back when DNA sequencing of natural product pathways was hard and expensive to do. As I said, Brian is …

… and released by the US Department of Energy (DOE) Joint Genome Institute (JGI) are subject to the following Data Policy. It is our mission to support open data and information sharing. We also recognize the need to have a limited and time-sensitive protection of certain types of data to support their use by …