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… and AI-driven analyses that convert biological information into actionable insights and solutions. Genome-enabled biology provides solutions to strengthen …

… DAN: You’re listening to the US Department of Energy Joint Genome Institute’s “Natural Prodcast,” a podcast about the … and you can still make more of it, then you start going into human trials or animal trials first, and going through … know, a very long, very expensive process. And so, drug companies really needed ways to kind of short-circuit that, and …

… Udwary: You’re listening to the Department of Energy Joint Genome Institute’s Natural Prodcast, a podcast about natural … be her room now but, well, it became my office due to the pandemic. And she’s sleeping in our bedroom together with us … it will be really good to maybe start with how did you get into this field? How did you get into natural products? …

… for every episode we put out. I actually put a lot of time into preparing those transcripts, so I hope somebody’s going … to cancer cell lines. So, that was introduced in Japan as a very first example. So the enediyne was introduced … natural product – they also often surprise us by giving us insights, inspires us to discover the fundamentals and then …

… Genome to Enzymes and Pathways focuses on discovering and … vital to DOE missions. Using bioinformatics tools and genome portals, we study lignocellulose decomposition, CO2 … supports researchers exploring how to convert sequence into functional assessments. The team has a research & …

… collaborative user projects, the JGI’s Plant Program delves into the natural world’s potential to address global … photosynthesis — the process that transforms solar energy into chemical energy — and its implications for carbon … communities affect plant growth and productivity. These insights have the potential to inform strategies that …

… 20 years of industry experience — and an opportunity to expand the JGI’s portfolio of user companies. Now the Department of Energy is uniting National … accessible, AI-ready large-scale data repositories for genome information with analysis tools for mining and …

… discoveries and catalyzing a major transition of biology into data science.  Research in the Kyrpides group focuses … 2014), unearthing hundreds of thousands of new viral genomes and their predicted hosts (Nature 2016, Science … 2018, Molecular Cell 2019) and massive reconstruction of genomes from uncultivated microbes (Nature 2019). Other …

… small genes assembled to less than 5kb in length, cloned into vector of choice Glycerol stock of sequence verified … Fungal Minimal Draft Lower coverage short-read whole genome shotgun sequencing Assembly, annotation ( Mycocosm ) … structural rearrangements, alignment files 384/454 Fungal Transcriptome RNA for expression profiling and genome …

… Download plant, algal, fungal and microbial genomes and metagenomes — top-quality genomic data, open to all researchers. … for comprehensive access to information regarding genome and metagenome sequencing projects, and their associated metadata, … analysis and annotation of all publicly available genomes from three domains of life, in a uniquely integrated …

… ago when we were at the height of the initial spread of the pandemic in Europe. So if there are any kind of dated … than it is now. Or a little more– yeah, put more rationale into drug discovery by knowing what these things actually do … Usually, in a lot of cases, we still have to go through publications to get proteins, and their functions, and all …

… bit of background: Mark is a friend of mine from the company that we used to work at together called Warp Drive Bio, … So maybe we could start with that background – what got you into secondary metabolism, besides being forced to work with … to go in the next couple years. And hopefully, some of the insights that we glean from that will be broadly applicable …