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… UDWARY: You’re listening to the Department of Energy Joint Genome Institute’s Natural Prodcast, a podcast about natural … very fast that I thought– DAN UDWARY: Yeah, there’s no selective pressure to keep them, right? NADINE ZIEMERT: Yes, … Usually, in a lot of cases, we still have to go through publications to get proteins, and their functions, and all …

… DAN: You’re listening to the US Department of Energy Joint Genome Institute’s “Natural Prodcast,” a podcast about the … and my job is to do cool research, and also to talk to the wider natural products community about what they need to … what we’re calling a Primer. We wanted to try and give a general audience some of the basics of natural products …

… off today with my interview with the Director of the Joint Genome Institute and head of the Secondary Metabolites … my undergraduate in microbiology and then PhD in microbial genetics in the UK. And came across to the US for a couple … help the Society grow. And so I’ve been the chair of the publications committee for the last, what is it now, five …

… DAN: You’re listening to the US Department of Energy Joint Genome Institute’s “Natural Prodcast,” a podcast about the … see as the overall “theme” of your research? I know you’ve generally worked in various marine organisms. Except during … sequence into an antibiotic that kills bacteria through a specific mechanism. Or whatever that peptide might be doing. …

… Research in the Eloe-Fadrosh group focuses on using genome-resolved … computational approaches to sift through thousands of metagenomes for signatures of viruses and novel microbial … on the assembly of metagenomic sequence data into microbial genomes, which is of fundamental value to improving our …

… The JGI’s Microbial Program focuses on using cutting-edge sequencing, annotation and analysis techniques to explore the vast … energy and ecosystem management. The program aims to generate high-quality genomic datasets, particularly for … driven prioritization lists for laboratory isolation and genome sequencing of underexplored bacterial and archaeal …

… And we’ve done some work with those and have a couple of publications out there on the chemistry. There’s so much … done. And more importantly, what we know is they’re quite selective in some way for antifungal activity. They are … almost never Actinomycetes. And so when we look at their genomes we don’t get the same kind of information that we …

… is focused on the discovery and characterization of novel bacterial, archaeal and eukaryotic microbes and viruses in environmental sequence data. We use multi-omics (metagenomics, metatranscriptomics, single cell genomics and phylogenomics) and machine learning …

… Program works to uncover the roles of small molecules in biological systems, linking them with genomic data to enhance our understanding of genome science, organisms, and ecosystems at the molecular … metabolomics fuels the discovery  of novel metabolites, genes, and proteins. It also enables exploration of energy …

… have– there were some isolated cases but it wasn’t as widespread as we have today. And the sad truth is MRSA and … I think on COVID that we’re getting ready to submit for publication and have found some interesting hits for that as … it’s not that easy. There are still not that many plant genomes, certainly nowhere close to bacterial kinds of …

… collaborative user projects, the JGI’s Plant Program delves into the natural world’s potential to address global challenges by exploring plants’ role in capturing carbon, detoxifying soils, … improve the accuracy of functional predictions and speed up genome analysis. Additionally, the Plant Program is …

… DAN: You’re listening to the US. .Department of Energy Joint Genome Institute’s “Natural Prodcast,” a podcast about the … a course. So this is taught at over 270 places now worldwide with a rate of around 10,000 students a year. And that … that get produced changes in response to different selective pressures. It’s really hard to assay because …