Search

… schedule. This should be coming out on the first Thursday of the month, just like I promised. Now I just have to make … sensing and its effects on regulation of natural product biosynthetic pathways, which led her to a successfully … Cyclic Peptides Synthesis of Gamma-Butyrolactone Hormones Enables Understanding of Natural Product Induction Betsy's …

Biology is currently experiencing a revolution brought on by rapid developments in genomics and other omics technologies.  The exponential growth of DNA sequencing data, coupled with recent computational … Science 344(6186):909-13 … Research Efforts … Selected Publications … For further details, please reach out to the …

… … DAN UDWARY: You’re listening to the Department of Energy Joint Genome Institute’s Natural Prodcast– a … syntenic units that are actually are constructing a BGC, a Biosynthetic Gene Cluster. So we do have enough data, and if … of natural product biosynthesis in bacteria ” The ActDES publication came out after we talked. It looks like a great …

DAN UDWARY: You’re listening to the Department of Energy Joint Genome Institute’s Natural Prodcast, a … and how we do it here and maybe give an example of a recent publication. ALISON TAKEMURA: Awesome. Yeah, let’s dive in, … trying to locate and sequence and get the information on biosynthetic gene clusters. And I’ll explain all this. So …

… r ecombinase- a ssisted  g enome  e ngineering ( CRAGE ). CRAGE enables scientists to insert large pieces of DNA (up to 60 … University of British Columbia, recently deployed CRAGE to rapidly label  E. coli  in order to monitor population …

The JGI’s Metabolomics Program works to uncover the roles of small molecules in biological systems, linking them with … metabolomics fuels the discovery  of novel metabolites, genes, and proteins. It also enables exploration of energy and nutrient exchange, as well …

The JGI’s Microbial Program focuses on using cutting-edge sequencing, annotation and analysis techniques to explore the vast and diverse world of microbes. Studying bacteria and archaea, including those … energy and ecosystem management. The program aims to generate high-quality genomic datasets, particularly for …

… … DAN UDWARY: You’re listening to the Department of Energy Joint Genome Institute’s Natural Prodcast, a … evolution. And I could see a certain time span within these biosynthetic gene clusters. There’s gene fusion going on, … Usually, in a lot of cases, we still have to go through publications to get proteins, and their functions, and all …

… for you here today. We got the opportunity to talk to one of the real legends of natural products, Professor Bill … normal cells, particularly your hair cells, which are also rapidly growing, the cells in the mucosa lining of your … They’re gram-negative bacteria. But we want to see those biosynthetic gene clusters that are making these alkaloids. …

… know that that’s ever necessarily like a good description of anyone because chemistry means a lot, especially when … And we’ve done some work with those and have a couple of publications out there on the chemistry. There’s so much … in natural products is that we don’t know what all the biosynthetic gene clusters look like.  DAN: For sure.  …

Research in the Woyke laboratory focuses on the utility of single-cell methods to access genetic material of uncultivated taxa of interest. One such … … Research Interests … Former Lab Members … Selected Publications … For further details, please reach out to the …

… uses advanced sequencing technologies to decode the genomes of microbes in their natural environments. This work … along with their associated viruses and mobile genetic elements. Beyond exploring and characterizing … and their metabolic functional potential. This research enables us to better understand how microbial communities …