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… Every approved proposal starts with a User Agreement — before any work can begin, including the submission of … Appendix identifies the type of work or specific proposal to be covered under the Agreement. The signing official must … rights in technical data, project reporting to the DOE, and publication requirements. An official with authority is …

… time, we’ve got a great interview with Ben Shen, from the Scripps Research Institute in Jupiter Florida. This interview … understand how nature is making compounds, but we are also applying CRISPR technology, anything as genome editing, … why the stereochemistry was that way. And he told me, it’s enzymes. It’s magic.  BEN:  Yeah, right.  DAN: I thought …

… Dan Udwary: Hey, Alison Takemura: Hey, Dan. Dan Udwary: Today we’re going to talk to Kate Duncan. And Kate is– I … to talk to her about a whole list of things. So we have a Scripps background shared together, although I don’t think we … is a whole bunch of information that maybe never makes its publication. And these are little tips, you know, how to …

… Hey, everyone. I’ve got a great episode for you here today. We got the opportunity to talk to one of the real … legends of natural products, Professor Bill Fenical from Scripps Institution of Oceanography in San Diego. Bill is a … 20S proteasome. The proteasome in the cell is a bundle of enzymes that is used to degrade proteins, peptides, that are …

… Dan Udwary: You’re listening to the Department of Energy Joint Genome Institute’s Natural … some of these enormous genes that encode these very large enzymes. And I was like, OK, wow, these are really cool. And … using machine learning models, that very tiny precursor peptide, encoding genes that encode the very small precursor …

… DAN: You’re listening to the US Department of Energy Joint Genome Institute’s … one interesting thing is though, you might have the same backbone gene synthases, but having a different decoration … I wish we could predict. I wish we could look at these enzymes and predict, and really place it to structure. …

… Our research is focused on the discovery and characterization of novel bacterial, … data. We use multi-omics (metagenomics, metatranscriptomics, single cell genomics and phylogenomics) and machine learning to identify new divergent lineages and expand the Tree of …

… The JGI’s DNA Synthesis Program supports a wide range of projects, from single-gene synthesis to the synthesis of entire chromosomes, advancing the … collaboration with U.S. and international scientists to drive innovations that align with DOE's missions. …

… DAN UDWARY: Hey everyone and welcome back to a new session of Natural Prodcast. I’ve got two things I … close enough to energy inputs. So this is– for us, that’s dripping water, percolating through the soil through leaf … what led me to natural products. So after realizing that enzymes were specific for their substrates, that you …

… See below for a list of Frequently Asked Questions about our proposal submission process. You can review … successful letters of intent and submissions at the bottom of the page.  … Review the list of open calls ; click on the call link to see specific details including project types supported, …

… group (ICBG) based in Panama and was dual there and at Scripps where I first met Dan. I think you were almost … And we’ve done some work with those and have a couple of publications out there on the chemistry. There’s so much … it interacting with, like, a binding pocket for one of the enzymes, so something that’s metal dependent? Is it– and we …