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… get to the DNA sequence – sequences for the genes that code for the proteins that produce secondary metabolites. Do … developed to the point that you could understand the genetics of secondary metabolism, it became possible to do … an organism. But some of those pathways might not be tractable to synthesis. So synthesis is still very expensive and …

… like Streptomyces , but circular. 10% of the genome encoded natural product pathways. Dan: Yeah, that’s kind of a … was fun having, you know, working with a student who was a geneticist, having them think like a chemist and thinking … You know, I think petroleum products allows us fantastic flexibility in the types of chemicals that we can make. And …

… a symbiont, for example, of an ant. So these are very stable interactions that have been evolving for 300 million … find any new genomes, new areas or regions or loci, that encode for new, truly chemical dark matter BGCs. That’s the … So we had a series of criteria to say this is a bunch of genetic material that exists in one copy, and it is …

Program uses advanced sequencing technologies to decode the genomes of microbes in their natural environments. … along with their associated viruses and mobile genetic elements. Beyond exploring and characterizing … microbial activity measurements, such as quantitative stable isotope probing (qSIP)-metagenomics and …

… a room with you, Dan. And to be actually sitting across the table from you.  DAN: Absolutely. It’s been a while. Talking … my undergraduate in microbiology and then PhD in microbial genetics in the UK. And came across to the US for a couple … and we got a screening platform set up. And we got the genetic engineering set up. And we were kind of off to the …

Moore on the Salinispora project,  so this is pretty comfortable territory for us, and I’m grateful to be working with … deterrence and rendering some organisms just simply unpalatable. And we know that this is one of the major adaptations … for culturing, and then of course using modern phylogenetic tools measuring genes, the 16S gene, and comparing …

… production. A reference genome for the sugarcane cultivar R570 has been  published in  Nature by an international consortium. With the genetic code of sugarcane, researchers were able to map the location …

The Micro-Scale Applications group explores the genetic makeup of natural microbial communities using a … Team    … The JGI uniquely offers the first quantitative Stable Isotope Probing (SIP) Metagenomics pipeline that … after first imaging with various microscopy techniques … Stable isotope probing metagenomics: … Single cell: … For …

… a timeline like this, researchers would normally craft a genetic clock based on its divergence with a  different … relative to one another. This change occurs at a predictable rate, enabling researchers to use the genome assembly to calibrate their genetic clock.  Various researchers around the globe were …

… to bacteria, yeasts and algae previously with little to no genetic tools enabling heterologous expression and …