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… annotate, and bin viruses from metagenomes. mSystems 9:e00888-24. https://doi.org/10.1128/msystems.00888-24 … of hypermutation in the global microbiome. Nat Commun 12, 3076. https://doi.org/10.1038/s41467-021-23402-7 Roux, S. … with long standing virus-host interactions. ISME J. 15, 1569–1584. https://doi.org/10.1038/s41396-020-00870-1 Roux, S. …

… are very stable interactions that have been evolving for 300 million years, that could be a reasonable number if you … of years in these particular niches, produce probably 20 or 30 more metabolites, which have this particular feature of … particular pathway. So all these BGCs encode between 80-90% of all known genes. Or genes that you can put a name …

… by watching Amanda Hurley’s presentation from the 2019 JGI Genomics of Energy & Environment Meeting.] He’s also a … have no extra genes hanging around, they still dedicate 20-30% of their genome to secondary metabolism. So it’s very … that’s really popped up at funding agencies and the popular news recently because a lot of soldiers in the Iraq and …

… wasn’t an MRSA strain at the time because that was in the 1980s. I’m showing my age now. So early 1980s we didn’t have– there were some isolated cases but it … plants and bringing them back is not your jam, the good news is there’s this amazing resource that can be provided …

… biology got more sophisticated around the 80s and the 90s. And so we started to be able to explore DNA sequencing … your cultures, but then you’re going to find another 20 or 30 secondary metabolism pathways that you didn’t even know …

… anybody in natural product discovery in any field and even 30 years ago would say it’s the [key to] success. And that … at Scripps, I guess, 22 years ago. And it’s over 130 steps to make everninomicin. DAN UDWARY: Yeah, one of … Unfixable in the sense that if it’s going to require 130 steps to make an analog, it’s not fixable. But if we can …