Search

… The mission of the Joint Genome Institute is to serve the scientific community as a user facility pioneering functional genomics to solve the most relevant bioenergy and environmental problems.  The … as needed), and the work plan is written into a Statement of Work document. …

… DAN: You’re listening to the US Department of Energy Joint Genome Institute’s “Natural Prodcast,” a … talk a lot about some of the technical challenges to that, most of which seem to be history.   I should mention that … usually, these days, you’re probably going to do a complete genome sequence before you know you do a whole lot …

… would be Katherine. Dan Udwary: Right. Kate Duncan: But most people that know me call me Kate. Dan Udwary: Great. So … here today, and we wanted to talk to her about a whole list of things. So we have a Scripps background shared together, … Right? But it’s all there. Like, the puzzle is pretty much complete, might be a few places in the wrong place, but for …

… know that that’s ever necessarily like a good description of anyone because chemistry means a lot, especially when … and at Scripps where I first met Dan. I think you were almost finishing when I was getting there but–  DAN: Yeah. I … genome sequence, in about 40% of the genome the genes were completely unidentifiable. You had no idea what they were …

… DAN: You’re listening to the US Department of Energy Joint Genome Institute’s “Natural Prodcast,” a … structurally resolved in the 1980s, they were known as the most toxic molecules, and that human beings know, today, for … natural product producing organism, the Actinomyces, was completed in early 2000s. One of the major discovery from …

… characteristics — creating many different ways of processing nitrogen. To boost crops more efficiently in … of Lawrence Berkeley National Laboratory (Berkeley Lab). He completed this work with collaborators at the University of … the JGI provided DNA synthesis capabilities to enable functional testing of these enzymes. Yasuo Yoshikuni, head …

… DAN UDWARY: Hey everyone and welcome back to a new session of Natural Prodcast. I’ve got two things I wanted to tell you about in this introduction. First and foremost, our interview this week is with Professor Brian … called Ecopia was talking about a gene cluster a week. They completed a gene cluster per week. And that really got me …

… Mass spectrometry based metabolomics Below is a table of standard product offerings, including a description of the product and … sequence data to  SRA at NCBI once the standard analysis is complete. Raw metabolomics data is submitted to the  MassIVE … de novo assembly. For counting: text file of gene counts (mapped against reference transcriptome or de novo assembly), …

… you the boilerplate questions that I try to tend to ask to most people. So one of those is like, what’s your origin … trying to understand that system is just not possible from– completely understanding the system is not possible from the … on that. And we are working on making a great big BiG-SLiCE map out of all this. BiG-SLiCE is a comparative analysis …

… DAN: You’re listening to the US Department of Energy Joint Genome Institute’s “Natural Prodcast,” a … but there you go. A tiny bit of background on this: Most of the machinery in any living organism are proteins, … the “Non-Ribosomal Peptide Synthetases” or NRPSs. These are enzyme systems that grab amino acids and stick them together …

… synthesis, and metabolomics at the JGI for projects of relevance to Department of Energy (DOE)  Mission Areas . … call is for PIs who have never led a JGI project, and the Functional Genomics call is for projects that translate … into biological function. The  New Investigator and Functional Genomics calls do not require an LOI.  Projects …

… been a sort of evolving trajectory. I think, you know, most scientific careers are like that, in that they they … database which is now shared with the whole community in a completely free and open manner. But it is also … having a better understanding of how these, I guess, the mapping of the masses and the ions to structure in a …