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… And you have these different types of particulate like 2.5, 10 PPMs and just the size of the particle and how far they … been working on that we sequenced the genome. And it has 17 resistant genes on a plasmid that’s actually– it’s pretty … pile of data. When I looked this morning, we were up to 1.1 million genomes. JACLYN WINTER: Wow. DAN UDWARY: And I …

… people what that number is. BETSY PARKINSON: So micromolar, 10 to the negative 6th. Nanomolar, 10 to the negative 9th. Picomolar, 10 to the negative 12th. DAN: Yeah. So very-- BETSY …

… probably heard of the Salem Witch Trials back in the what? 15th, 16th century.  ALISON: Yeah, I lived in Massachusetts for a …

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… into DNA by active microbial populations (Hungate et al. 2015). With the development of high-throughput SIP (Nuccio et … strategies across environmental microbiomes. mSystems0:e01744-24. https://doi.org/10.1128/msystems.01744-24 Oliver, … Acids Research , Volume 51, Issue D1, 6 January 2023, Pages D723–D732, https://doi.org/10.1093/nar/gkac976 Roux, …

… Wisconsin. Like we discussed in the primer podcasts ( part 1 here , part 2 here , and part 3 here ), which you should … first started out the natural product community was almost 100% bacterial. Only people working in mycotoxins worked … – you know how that’s a big deal now. You go to all these meetings on microbiomes they only talk about the bacteria. …

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… and I did that. And looking at all those art history photos of the, you know, various old buildings in in Rome … pairs. It was not linear, like Streptomyces , but circular. 10% of the genome encoded natural product pathways. Dan: … Brad: Yeah, at that time, that was new, right? Like, my god 10% of the genome makes small molecules that have, you know, …

… metabolism. Hey everybody, this is Dan with episode 13 of National Prodcast. This continues our little section … very important, because then you can see it as a fitness landscape, which is very common in evolutionary biology but, … microbiologists have ignored this idea of fitness landscapes. So, in one hand, you could imagine that there is a …

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