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… oftentimes will bind to receptors within biosynthetic gene clusters. Specifically, these are Tet repressors that … put them onto the bacteria to see if we can then see changes. And we're primarily doing this by mass spec seeing … that you can turn on the natural product, say clusters or expression systems so that-- BETSY PARKINSON: Exactly. DAN: …

… the active site of an enzyme. So there is no promiscuity, generally speaking, in primary metabolism. Nevertheless, … example, in terms of the stereochemistry, such that single changes can lead to a particular high activity towards a … to find the clueless ones. ALISON TAKEMURA: Is there just identifying these gene clusters that gets you to– I guess, …

… starts with a User Agreement — before any work can begin, including the submission of samples for sequencing, or … your Host Institution and LBNL is required. NOTE:  If a PI changes academic institutions or a new PI is named during … Manager must be notified immediately. Either of these changes may require new signed paperwork, and getting new …

The focus of this group, in recent years, has been to bring generalizable … with little to no genetic tools enabling heterologous expression and functional exploration.  The developed …

… … DAN: You’re listening to the US Department of Energy Joint Genome Institute’s … After I got my undergraduate degree, which was in general biology, I joined the Peace Corps. And when I was … looking at that I’m a very visual person. So, when we make genetic mutants in a fungal isolate, I can see something …

Fine-tuning metabolic gene expression helps identify variants in yeast genes. The Science Scientists have developed a more nuanced …

Metabolomics strengthens -omics technologies at the JGI by identifying the actual molecules present in an environment that … products At JGI, in-depth molecular profiles are generated for metabolites extracted from a variety of …

… … DAN UDWARY: You’re listening to the Department of Energy Joint Genome Institute’s … of it. So it wasn’t only chemistry or only biochemistry or genetics. It was also ecology. It was also evolution. It was … yeah! That makes total sense because as that A domain there changes, then that would happen then!” And like, oh, you see …

In honor of the JGI's 25th anniversary in 2022, we have … Flagship Plants . Since 2007, the JGI has been working on identifying switchgrass genes related to biomass production, drought tolerance, and …

… and actually get to the DNA sequence – sequences for the genes that code for the proteins that produce secondary … can see how they work, we can’t always see how to make the changes to make them do whatever we want them to do. And … if we can improve technology, for assembly and cloning and expression, we should be able to actually make the chemical …

A tall native plant of the North American prairie, switchgrass ( Panicum virgatum ) has long been a tantalizing potential biofuel feedstock. But switchgrass has a … traits — height, biomass, hardiness to cold, etc. — to its genes. The undertaking took shovels, trucks — and more than …

The JGI’s Microbial Program focuses on using cutting-edge sequencing, annotation and analysis … energy and ecosystem management. The program aims to generate high-quality genomic datasets, particularly for … single cell approaches. This includes linking strain-level genetic variation to ecological niche adaptations.  Single …