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…   Metabolomics strengthens -omics technologies at the JGI by identifying the actual molecules present in an environment … JGI Metabolomics Platform delivers rich metabolite profiles from diverse biological and environmental samples using … experimental samples, including organisms (e.g. microbes, fungi, plant), media in which they grow, as well as …

… conversation with Aaron Puri. He is an Assistant Professor from the Chemistry department at the University of Utah, so … lactone based systems. So you have these synthase enzymes that can make the signal. You have the signal … to identify what’s being made. In some cases it might be novel, in some cases it might be– might be a known structure …

… Molecular Cell 2019) and massive reconstruction of genomes from uncultivated microbes (Nature 2019). Other projects in … of the functional dark matter as well as the development of novel methods to enable large-scale comparative analysis, … (2018) Programmed DNA destruction by miniature CRISPR-Cas14 enzymes. Science 362(6416):839-842. Duerkop BA, et al. …

… we have our conversation with Professor Alison Narayan, from the University of Michigan. I hope she’ll accept this … as exploring and exploiting biocatalysts – that is, using enzymes to do chemical reactions. Obviously, in my work, in … where us genome miners get really jazzed about finding enzymes that do unusual or unprecedented chemistry. So it’s …

… the exploration of secondary metabolites across bacteria, fungi, algae and plants. These molecules, which are not … reservoir of secondary metabolites produced by bacteria, fungi, algae and plants. These compounds are key to … interactions with their environments and with each other, from defending against predators to aiding in symbiotic …

… real legends of natural products, Professor Bill Fenical from Scripps Institution of Oceanography in San Diego. Bill … an exploration into the secondary metabolism of some more novel marine bacteria. You know, I first met Bill as a … 20S proteasome. The proteasome in the cell is a bundle of enzymes that is used to degrade proteins, peptides, that are …

… that there wasn’t enough application there. And so I moved from there to plant natural products, getting a PhD in … But if they’re not clustered then maybe we’re not really identifying them very well. For sure. But plants certainly … it interacting with, like, a binding pocket for one of the enzymes, so something that’s metal dependent? Is it– and we …

… This time, we’ve got a great interview with Ben Shen, from the Scripps Research Institute in Jupiter Florida. This … to kill cells. So it’s really remarkable in terms of a novel mechanism, how a small molecule can kill. So that … why the stereochemistry was that way. And he told me, it’s enzymes. It’s magic.  BEN:  Yeah, right.  DAN: I thought …

… week, we have our conversation with Professor Eric Schmidt, from the University of Utah. I’ve known Eric for a long time … way of making proteins, with a ribosome. Then, some other enzymes chop the protein into smaller pieces, and other … marine organisms. Except during the time that we worked in fungi. But what do you see as the overall theme of your …

… DNA Synthesis Program supports a wide range of projects, from single-gene synthesis to the synthesis of entire … Genome to Enzymes and Pathways focuses on discovering and characterizing enzymes and pathways vital to DOE missions. Using … analysis and annotation of all publicly available genomes from three domains of life, in a uniquely integrated …

… lot going on, so I took a little break, but I’m hoping that from here I can get back to a regular schedule. I’m going to … Gluconibacter .  And that got me back a little bit to redox enzymes and looking at gene regulation. And then from there, … which, at least at the time, was called Inatreq . It’s a fungicide that is active against Sartoria which is a really …

… prefers to be known among friends in natural products. He’s from Langebio in Irapuato, Mexico, and an incredibly bright … will be very flexible. They will allow promiscuity and the enzymes are driving the production of these compounds, … to find the clueless ones. ALISON TAKEMURA: Is there just identifying these gene clusters that gets you to– I guess, …