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At the end of the day, all the content produced by microbes the result of millions of years of evolution. And … by bacterial or fungal metabolism by microbes, will have a functional role. We started from that. Evolution doesn’t … the active site of an enzyme. So there is no promiscuity, generally speaking, in primary metabolism. Nevertheless, …

… and he has a project with the JGI to synthesize the genes for and explore the chemistry of quorum sensing … of molecules can be thought of as signals or have other functions depending on their concentration and their … ecology community to be able to better predict how their microbes are interacting with each other from sequence …

… challenges. Oh, the magical world of the cow stomach. Rumen – and its microbes – are really a powerhouse. Rumen microbes have the … environmental samples — to identify over 27,000 microbial genes. These genes were identified based on their potential …

… the scientific community as a user facility pioneering functional genomics to solve the most relevant bioenergy and … systems biology data and tools to help predict biological function.   To jointly support these missions, and to expand … the completion of a project, the JGI makes the assemblies, gene annotations, and analyses available to the community at …

… on large-scale sequencing efforts that survey the vast phylogenetic and ecological diversity of fungi and algae, … strains. This approach allows for the identification of key functional traits that have direct applications in bioenergy … members of microbial communities, cataloging gene markers, and producing environmental genomes to support …

… call is for PIs who have never led a JGI project, and the Functional Genomics call is for projects that translate genomic information into biological function. The  New Investigator and Functional Genomics … the completion of a project, the JGI makes the assemblies, gene annotations, and analyses available to the community at …

… as successful submissions to our CSP New Investigator, CSP Functional Genomics, and Facilities Integrating … PIs who drafted them.  … Elucidating Sphagnum microbiome genetic interactions for improved growth at elevated … strategies in a cosmopolitan and abundant soil bacterium: genetic microdiversity or core metabolic flexibility? … …

… sentence. I think that sometimes, we think about enzyme function is we think about the natural function versus can … could have arisen from. DAN UDWARY: OK, so sort of a phylogenetic reconstruction kind of a thing. ALISON NARAYAN: … to test that hypothesis through site-directed mutagenesis, we would end up with dead enzymes. So often, when …

… and wondering what those … what those were and how they function. So I worked on a team at the Broad that was looking to develop new methods for DNA sequencing of microbes. And what kept breaking our methods was these damn … that can’t live without their host. They have no extra genes hanging around, they still dedicate 20-30% of their …

It was unpublished at that point. But people would push out gene clusters maybe once a month at most. Maybe twice a … them on a regular basis. So they are full of terrestrial microbes. So they’re open ecosystems. They’re not sealed off … ATP synthase.” On everninomicin biosynthesis: “EvdS6 is a bifunctional decarboxylase from the everninomicin gene …

… my undergraduate in microbiology and then PhD in microbial genetics in the UK. And came across to the US for a couple … it’s really about what are they doing. And so it’s really functional genomics. And there’s a lot of sequencing based … But they really span our core science programs which are microbes, and fungi, and algae plants, synthetic biology. …

The Micro-Scale Applications group explores the genetic makeup of natural microbial communities using a … the quality of single-cell genomes and directly link functional information with individual cells. Research Team  … sequence analysis to recover the genomes of uncultivated microbes. We also apply labeling strategies that allow us to …