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… oftentimes will bind to receptors within biosynthetic gene clusters. Specifically, these are Tet repressors that oftentimes turn off these biosynthetic gene clusters. And so we've been really interested in trying … interested in their connection to these biosynthetic gene clusters. DAN: OK. So maybe if we talk in a really …

It was unpublished at that point. But people would push out gene clusters maybe once a month at most. Maybe twice a year, a full gene cluster would come out. And it was a very exciting … this guy at a company called Ecopia was talking about a gene cluster a week. They completed a gene cluster per week. …

… my undergraduate in microbiology and then PhD in microbial genetics in the UK. And came across to the US for a couple … spheroides . And that got me really interested in microbial gene regulation and some pathways. And I thought I’d take an … got me back a little bit to redox enzymes and looking at gene regulation. And then from there, I went to Dow …

Program supports a wide range of projects, from single-gene synthesis to the synthesis of entire chromosomes, … the program enables the design and synthesis of complex genetic pathways and biosystems. It The program fosters … in advancing functional genomics, focusing on developing genetic systems that can address global energy and …

… the active site of an enzyme. So there is no promiscuity, generally speaking, in primary metabolism. Nevertheless, … antibiotic is really an antibiotic in nature, what is the general belief is that that is the case when there is a … the regulation off, rather than negatively get rid of the genes from their genome. FRANCISCO BARONA-GOMEZ: Exactly …

… percentile*) DNA Synthesis Constructs <5kb in size Single gene or multiple small genes assembled to less than 5kb in length, cloned into … clone 102/NA DNA Synthesis Constructs 5-10kb in size Single gene or multiple small genes assembled totaling 5-10kb in …

… conditions, with only a small portion of the biosynthetic gene clusters (BGCs) being expressed. The program works to … uncover these hidden biochemical resources by exploring the genetic pathways responsible for their synthesis. The … developing computational tools for predicting biosynthetic gene clusters (BGCs), advancing pathway analysis, …