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… … DAN: You’re listening to the US Department of Energy Joint Genome Institute’s … so enediynes are this really cool class of natural product compounds, Alison. They are – if you can imagine – two … natural products of microbial origin is around 30,000 from fungal, and a 40,000 from bacteria. Okay? And among the …

… as well as target cycle times from sample receipt to completion of standard analysis.  Raw data is provided … DNA Synthesis Combinatorial libraries Multiple genes synthesized and cloned into a vector of choice in various … to determine coverage of variants depends on project Fungal Minimal Draft Lower coverage short-read whole genome …

Developed in 2017, the PDT was established in part to help better-connect industry to JGI resources, as well as … rapidly engineer a Clostridium strain for the production of biofuels and bioproducts from low-cost gas feedstock. For …

… … DAN: You’re listening to the US Department of Energy Joint Genome Institute’s … episode is our conversation with Nancy Keller, a fantastic fungal natural products researcher from the University of … of mycotoxigenic fungi. It’s actually easier to find new compounds, natural products, in the lab, honestly, by …

… in natural products right. There’s many different avenues toward chemistry. But that’s kind of where I had you. How … what we know is they’re quite selective in some way for antifungal activity. They are also, some of them, are … being called an egg defense model. And so maybe there are compounds in there that we know there are compounds in there …

… … DAN: You’re listening to the US Department of Energy Joint Genome Institute’s … products is an older term for the special, natural chemical compounds that you find in plants, fungi and bacteria, … where this happened have a tendency to be susceptible to a fungal infection of rye grain – a specific fungus, Claviceps …

… annotation and analysis of (meta)genomic, (meta)transcriptomic, and functional genomic data and serving them to users via the Integrated Microbial Genomes & Microbiomes … based on their pairwise AF and ANI values, we were able to ascertain mis-assignment of species names in genomes …

… … DAN UDWARY: You’re listening to the Department of Energy Joint Genome Institute’s Natural … uses or applications– are the evolutionary nature of these compounds. At the end of the day, all the content produced … Yeah, so any metabolite, produced by bacterial or fungal metabolism by microbes, will have a functional role. …

If you stick around for the next few months, you’re going to hear my last interview with my co-host Alison Takemura, … a big idea that fits within our mission, we’re happy to help you figure out if it’s a good fit. Everyone we talked … And I think also the quality that we provide. So for fungal and for a lot of our eukaryotic genomes, all our …

… … Dan Udwary: Hey, Alison Takemura: Hey, Dan. Dan Udwary: Today we’re going to talk to Kate Duncan. And Kate is– I … as well. A lot of them have looked at applications like biofuels. Dan Udwary: Sure. Kate Duncan: But from a natural … is, do microalgae also produce natural products that can be helpful in producing biofuels? Because you had mentioned …

… . A minimum request of 1 Tb of sequence data is required to qualify for BERSS. For DNA synthesis requests, the … request falls below these thresholds, you will need to utilize a core facility instead. Proposals may not exceed … research in the development of cellulosic ethanol and other biofuels, advancing the federal initiative that seeks to …

… diversity of cell types and associated organisms, including fungal and bacterial symbionts, detrimental microbial … pathogens, and associated viruses that all contribute to a dynamic ecosystem. We are interested in how plants … ‘omics methods. Here we were able to capture both plant and fungal expression patterns in root cross-sections. … …