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… most of the people that I think we’ve talked to so far I either know personally, or have worked with directly, … good at finding and killing plants, so if you haven’t figured that out already from the book, not so great at growing … And yeah, it just kind of came together in the most delightful and unexpected way. So I had to leave with that …

… this conversation about why the ocean was basically unexplored until the 70s, and how diving was the catalyst of that. … UDWARY: So Alison, I’m really excited today. We have, by far, I think, one of the most decorated and legendary … is in an adjacent cell that is also your cell. But what makes chemotherapy work is not that the target is unique, …

… genome mining in cave microbiomes, and using engineered biosynthetic pathways and enzyme systems to do synthetic … later. JACKIE WINTER: It’s pretty amazing, though, how far we’ve come, though, too when you start talking about … existed for millions of years and relatively stable– no lights, constant temperature, constant humidity. And they …

… one that the Hawaiian bobtail squid is famous for is the light organ.  And the light organ houses Vibrio fischeri, … is about the size of your pinky nail has maybe 50 to a hundreds of these. And so Spencer and his group have done the … symbiosis, and a JGI project around ants and their fungus farms.  Relevant Links Some of the work we discussed about …

ALISON TAKEMURA: Hey, Dan. DAN UDWARY: So we’re back in our far corners of the world. So, yeah. ALISON TAKEMURA: That’s … I want to understand how secondary metabolites evolve– who makes them, how do they spread, why do they spread in a … of NaPDoS , this computer program which uses phylogeny to predict compounds. And so I really had to dig into all the …

… bacteria that I would say are are still fairly unexplored in terms of their natural products chemistry, and he has … with COVID that I’ve been able to go to in the community so far. But being here and then being at the Marine Natural … tundripaludum is my favorite and is again, maybe highlighting the people-centric aspects of the broader field and …

… a great program. This is one of my favorite interviews so far – you’re going to hear how passionate and enthusiastic … that Dan just described to you. So the enediyne referred to two carbon with a double bond. And “di” means two and … right? That’s the flavor of monoterpenoids. The very light natural product that gives you this fresh scent of the …

… products. He’s from Langebio in Irapuato, Mexico, and an incredibly bright guy who’s been thinking for a long time about … about a plant and a microbe interacting very stably. So it makes sense that you end up having a very unique on one … is an antifungal that will actually protect the fungal farms from other fungus that want to take advantage of that …

… has access to, which can be really weird and different, and makes for lots of variety in chemistry. The other way – the … that they make that are very potent in preventing predators from eating them. And so there’s a long history. … there, they tend to have a lot of chemistry in them. And so far people looking at that chemistry have focused on how …

… are active and if no additional signatures are required. Learn more about User Agreements and additional required documentation here .  … You can request a JGI Single … Metagenome and Single Cell (IMG/ M-ER) Fungal (Mycocosm) Algal (Phycocosm) … In general, data generated by the JGI …

So it’s super fun to hear about what folks are up to in a slightly different niche in chemical enzymology. So, we … to be done across science to to get a point where we can predict an enzymes synthetic capabilities. Also, along the … you can’t destroy, we’ll pick that one. DAN UDWARY: That makes sense, yeah. ALISON NARAYAN: Because we want everyone …