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… community itself works together to elicit new metabolite production. And we are also interested in how the jelly … Dan: Yeah. Well we need more people like you finding the molecules so then we can tie them back to the gene clusters … chemistry but I think that’s not necessarily – There are small molecules that host make as well. And so hosts and …

… metabolites across bacteria, fungi, algae and plants. These molecules, which are not essential for fundamental growth, provide critical advantages to the organisms producing them, and are often involved in defense, nutrient acquisition and communication. … realized under standard laboratory conditions, with only a small portion of the biosynthetic gene clusters (BGCs) being …

… of Natural Prodcast. A little bit of a bonus episode, since I’m off schedule, but this is an important one that … the normal amount that we get, which is already a fairly small number. We’re a very niche podcast. And so maybe if we … as an undergrad. And to me, looking at the chemistry of the molecules and then looking at how they were made was really …

… Hey, Alison Takemura: Hey, Dan. Dan Udwary: Today we’re going to talk to Kate Duncan. And Kate is– I should ask, you … around countries. And I was actually in Croatia on a small island off the coast in the Adriatic Sea, and I … on ionizing, so you’re essentially getting only a subset of molecules that will fly on an analytical instrument and be …

…   The Joint Genome Institute's Biodesign Platform capabilities support researchers exploring how to convert sequence into functional assessments. This is done by synthesizing … sequence design for assembly by Gibson, Yeast recombination and Golden Gate methods …

… strengthens -omics technologies at the JGI by identifying the actual molecules present in an environment that influence system … genome annotation, improves understanding of the role small molecules play in diverse biological systems, sheds … Find more details on the instrumentation we use and our …

… DAN: You’re listening to the US Department of Energy Joint Genome Institute’s … chains of amino acids. “Peptide” is just another word for a small protein. And it turns out that a lot of natural … interesting? And what we found is there are a lot of small molecules that are active, that are also found in the …

… you need to go back to your extract and try to purify the molecule that’s causing that test to be successful. Right? … of enzymes and sometimes those are referred to as “small molecules” because proteins are actually molecules … gene that’s likely to be involved in secondary metabolism – production, say of a certain molecule. If you can find one …

… tiny precursor peptide, encoding genes that encode the very small precursor peptides that end up being … clusters across different species, which all encode the production of either the same or similar molecules. And then of course, where you draw the boundary …

… Hey everyone. Welcome back to Natural Prodcast. This continues the series of interviews we recorded at the Society … as a simple organic chemist, can I make that big, beautiful molecule? And so I’d like to think I’ve evolved a bit since … UDWARY: Sure. ALISON NARAYAN: And so we usually start on small scale in the lab. So we’ll run things in like little …

… before we’re even thinking of genes and connecting genes to molecules, which is something that, you know, we take for … So we began to sequence that genome – it was a relatively small genome, about five and a half million base pairs. It … so we’ve done some work to try to do some elicitation of production and did some meta-T [meta-transcriptomics] on …

… into piloting and to finally get things into commercial production. So the full stretch of things. Full stretch all … big pathogen of wheat in cereal crops in Europe. And the molecule is derived from a natural product called UK2A that … like I said. And I’m part of that. It’s a few of us now, small little group. What’s your vision for us in our group?  …