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… to explore sequence-function relationships, advancing the discovery of new biosensors for biofuels and bioproducts. … tools that enhance biofuel production and biosystem design. High-throughput design and synthesis capabilities accelerate … Genome to Enzymes and Pathways focuses on discovering and …

… about several different pieces of her work, including bacterial quorum sensing and its effects on regulation of … pathways, which led her to a successfully funded JGI CSP project. And we also got to talk about work at her … trans in order to cyclize at that small of a ring, which is highly unfavorable. DAN: Oh, I did not know that. That's …

… level. Integrating genomics with metabolomics fuels the discovery  of novel metabolites, genes, and proteins. It … terrestrial biogeochemical processes, development of high performance plants and microbes, and understanding … ENVnet can be used in your custom Python applications but highly recommend using the workflow in  GNPS2 .   …

… such as those involving biosynthetic clusters, or high complexity combinatorial libraries.  We have developed … particular through adoption of lab automation enabling ever-higher levels of throughput. We also develop methods for efficient QA/QC …

… including especially metatranscriptomics, to better highlight and ultimately predict the main viral impacts in … and activity is driven by snowmelt and host dynamics in a high-altitude watershed soil ecosystem. Microbiome 11, 237. … Roux, S., Paul, B.G., Bagby, S.C. et al. (2021) Ecology and molecular targets of hypermutation in the …

… FY22 and later through the Community Science Program (CSP), Facilities Integrating Collaborations for User Science … for which JGI has not yet received samples as of Sep 30, 2021 are subject to a 2-year embargo to maintain the … Data from projects that received samples before Sep 30, 2021 and are ongoing are subject to the 2-year …

… with a broad range of experimental work on plants for drug discovery in antibiotics, anticancer, and now COVID. We also … challenge is, as the listeners know, even when you find a highly potent active compound that has a good cytotoxicity … screen, I think having assays that are amenable to – high-throughput testing is really important for us. In this …

… the user and no granting of funds.    Proposal Call FICUS CSP Large Scale CSP New Investigator CSP Functional Genomics JGI-TMF Critical Minerals and …

… BARONA-GOMEZ: Yeah, so any metabolite, produced by bacterial or fungal metabolism by microbes, will have a … will be very flexible. They will allow promiscuity and the enzymes are driving the production of these compounds, which, in turn, translate into a high chemical diversity. So that’s just the type of …

… lab now is use these as a resource for natural product discovery because we can genetically manipulate them. I … we’ll say methyl so we call them methylotrophs [ muh-thigh-luh-trophs ]. This is like, every square is a … cluster with me because it turns out that oftentimes in bacterial genomes if you have a quorum sensing system or the …

… enjoyed what he was doing so I wanted to be part of that discovery, and that magic that he was showing, and in his … two sequenced genomes of a Streptomyces , or gram-positive high GC organism.  Dan: Yeah, not a lot of natural product … JGI projects over the years starting with, you know, the CSP that we did and then leading up to today to some …

… and microbiology just followed me all the way through my high school days in England.  DAN: What did your dad do in … and new ways to recover spinosyns. And so we had a high throughput screening platform where we’d look at 10,000, … And so it was very much a co-Dow product.  DAN: Industrial discovery, yeah.  NIGEL MOUNCEY: Right. An amazing product, …