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… about several different pieces of her work, including bacterial quorum sensing and its effects on regulation of … pathways, which led her to a successfully funded JGI CSP project. And we also got to talk about work at her … trans in order to cyclize at that small of a ring, which is highly unfavorable. DAN: Oh, I did not know that. That's …

… level. Integrating genomics with metabolomics fuels the discovery  of novel metabolites, genes, and proteins. It … terrestrial biogeochemical processes, development of high performance plants and microbes, and understanding … ENVnet can be used in your custom Python applications but highly recommend using the workflow in  GNPS2 .   … In …

… to the user and no granting of funds.   Proposal Call FICUS CSP Large Scale CSP New Investigator CSP Functional Genomics Status CLOSED CLOSED ONGOING ONGOING …

… such as those involving biosynthetic clusters, or high complexity combinatorial libraries.  We have developed … particular through adoption of lab automation enabling ever-higher levels of throughput. We also develop methods for efficient QA/QC …

… with a broad range of experimental work on plants for drug discovery in antibiotics, anticancer, and now COVID. We also … challenge is, as the listeners know, even when you find a highly potent active compound that has a good cytotoxicity … screen, I think having assays that are amenable to – high-throughput testing is really important for us. In this …

FY22 and later through the Community Science Program (CSP), Facilities Integrating Collaborations for User Science … for which JGI has not yet received samples as of Sep 30, 2021 are subject to a 2-year embargo to maintain the … Data from projects that received samples before Sep 30, 2021 and are ongoing are subject to the 2-year …

… and microbiology just followed me all the way through my high school days in England.  DAN: What did your dad do in … and new ways to recover spinosyns. And so we had a high throughput screening platform where we’d look at 10,000, … Non-model Bacteria Check out the agenda for the JGI’s 2021 Annual Genomics of Energy & Environment Meeting   …

BARONA-GOMEZ: Yeah, so any metabolite, produced by bacterial or fungal metabolism by microbes, will have a … will be very flexible. They will allow promiscuity and the enzymes are driving the production of these compounds, which, in turn, translate into a high chemical diversity. So that’s just the type of …

… lab now is use these as a resource for natural product discovery because we can genetically manipulate them. I … we’ll say methyl so we call them methylotrophs [ muh-thigh-luh-trophs ]. This is like, every square is a … by Inverse Stable Isotopic Labeling . ACS Chem Biol. 2021 Aug 20;16(8):1332-1338. doi: 10.1021/acschembio.1c00329. …

… enjoyed what he was doing so I wanted to be part of that discovery, and that magic that he was showing, and in his … two sequenced genomes of a Streptomyces , or gram-positive high GC organism.  Dan: Yeah, not a lot of natural product … JGI projects over the years starting with, you know, the CSP that we did and then leading up to today to some …

… industry engagement through three primary routes:  … The CSP provides the scientific community at large with access to high-throughput sequencing and other resources at the JGI for …

… as exploring and exploiting biocatalysts – that is, using enzymes to do chemical reactions. Obviously, in my work, in … And you want to have good binding to your substrate and high turnovers. But if you have those things, can you also … are natural sequences, and we chose several of them to be highly related to enzymes that we have been studying since …