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… Biology is currently experiencing a revolution brought on by rapid developments in genomics and other omics … resistance. Cell . 184(13):3376-3393 Almeida A, et al. (2020) A unified catalog of 204,938 reference genomes from … Harrington LB, et al (2018) Programmed DNA destruction by miniature CRISPR-Cas14 enzymes. Science …

… Natural Products conference, which took place last January 2020 in San Diego. San Diego, of course, is the “home turf” … called Salinospora . This new genus was discovered by friends and colleagues at the Scripps Institution of … JGI projects over the years starting with, you know, the CSP that we did and then leading up to today to some …

… just deposit and take off. And so they must be chemically protected in some way and lo and behold it’s this bacteria. … you bring a unique perspective too? And so I was fascinated by – we spend a lot of time as natural products chemists and … working on that aspect and it’s quite active against some fungi. But we’re also really interested in distribution. So …

… The CSP and FICUS calls are open to both domestic and … Agreement must be signed before work can begin, and all CSP proposals are subject to JGI policies on Data Release and Publication .   Except for applicants to the CSP New Investigator call, investigators may have existing …

… hard it was – it felt kind of like training for a marathon by running at a high altitude! And a lot of us moved on to … on this: Most of the machinery in any living organism are proteins, which are made up of chains of amino acids. … marine organisms. Except during the time that we worked in fungi. But what do you see as the overall theme of your …

… the exploration of secondary metabolites across bacteria, fungi, algae and plants. These molecules, which are not … underexplored reservoir of secondary metabolites produced by bacteria, fungi, algae and plants. These compounds are key to … of BGCs are expressed under standard laboratory conditions by their native hosts. We are developing cell-free based …

… pathways, which led her to a successfully funded JGI CSP project. And we also got to talk about work at her … Sure. Definitely. So, I got my PhD with Paul Hergenrother at the University of Illinois at Urbana-Champaign. … like a lot of people hedge their way into natural products by starting out in synthesis and then discovering more-- …

… in stores and online, and there’s an audio version, read by Cassandra, and the paperback version will be available in … Diversity . And there’s something called the Nagoya Protocol on access and benefit sharing. And for a very long … just get a DNA sequence first. And there are plenty of software tools to find natural product gene clusters, and …

… natural chemical compounds that you find in plants, fungi and bacteria, basically all living things. When your … search away! If you like these primer episodes, let me know by emailing us to [email protected], or on twitter @JGI or … ecology. I studied Vibrio species in the ocean, so heterotrophic bacteria. Now, we didn’t get into secondary …

… National Program for Antarctic Researches (PNRA),  funded by the Italian Ministry of University and Research; all specimens collected and fungi isolated are preserved in the Culture Collection of Fungi from Extreme Environment, the Italian National …

… introduction in natural products, so I might just start out by asking you know how did you get started. I know you’re … that people work with are actually alpha or gammaproteobacteria. They just have this very restricted niche. … AARON PURI: Yeah. Right. And that’s you’ll find me in the woods then. [LAUGHTER] JACKIE: So we’re kind of across — …