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… metabolomics fuels the discovery  of novel metabolites, genes, and proteins. It also enables exploration of energy … biological and environmental samples — including microbes, fungi, plants and soils. Through a combination of … scientists are able to link metabolic activity with gene expression, providing deeper insights into functional …

… and he has a project with the JGI to synthesize the genes for and explore the chemistry of quorum sensing … some new way of thinking or technology, that’s usually very beneficial to the field. It’s very, very, very … cluster the products of the biosynthetic gene cluster is regulated. DAN: By the quorum sensing system. Yeah. AARON …

… with Christian, I started getting a little bit more into fungi and learning the differences of all the genetic … has been doing work in secondary metabolism. The very first CSP I ever worked on back in Brad’s lab, we talked about it … to a molecule that’s actually helping people and being beneficial in terms of medicine. And that’s something we …

… to the user and no granting of funds.   Proposal Call FICUS CSP Large Scale CSP New Investigator CSP Functional Genomics Status CLOSED CLOSED ONGOING ONGOING …

It was unpublished at that point. But people would push out gene clusters maybe once a month at most. Maybe twice a year, a full gene cluster would come out. And it was a very exciting … if you want– if you really want to, you can do heterologous expression. You can do homologous expression techniques and …

… in. All proposals must be written in English. … The CSP and FICUS calls are open to both domestic and … from any institution type and at any career stage. Generally, most users are able to work with Berkeley Lab.  … Agreement must be signed before work can begin, and all CSP proposals are subject to JGI policies on Data Release …

… and phytoplankton capture atmospheric carbon, helping to regulate Earth's carbon balance, to exploring the genetic basis of how plants have naturally adapted to varied … Centers. The  Plant Gene Atlas initiative develops gene expression catalogs across JGI Plant Flagship …

… of this is based on a really great paper that came out in 2020 where this is all explained in detail, so if you’d like … because otherwise it will be targeting a target that is not beneficial anymore, and instead of being a nice antibiotic … metabolomics, and natural products in plants, fungi, and microorganisms. If you want to collaborate, let …

… include exploration of the global diversity of alternative genetic codes (Science 2014), unearthing hundreds of … resistance. Cell . 184(13):3376-3393 Almeida A, et al. (2020) A unified catalog of 204,938 reference genomes from … Nature Biotechnol.  39(1):105-114. Schulz F, et al. (2020) Giant virus diversity and host interactions through …

… analysis to date of the modified DNA base 5mC variations in fungi. The Science Changing an A, C, T or G in a genome … In many organisms, 5mC is an important piece of how they regulate their genomes, but is not well understood in fungi. … between plants and fungi run the gamut from mutually beneficial to antagonistic. In fungi, 5mC is often found in …

… and BiG-SLiCE, and now the BiG-FAM database of biosynthetic gene cluster families. And he tells us about forthcoming … was a proposal on synthetic biology of engineering gene expression in bacteria – however, the professor was actually … metabolomics, and natural products in plants, fungi, and microorganisms. If you want to collaborate, let …

… bacteria there is more horizontal transfer. And so it’s beneficial then to have secondary metabolism in proximity … working on that aspect and it’s quite active against some fungi. But we’re also really interested in distribution. So … on increasing computational skills among biologists JGI CSP Proposal: Metagenomic mining of natural product …