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… pathways, which led her to a successfully funded JGI CSP project. And we also got to talk about work at her … oftentimes will bind to receptors within biosynthetic gene clusters. Specifically, these are Tet repressors that … But what was really interesting is when I started my lab in 2018, several papers came out right in a row all about this …

… focuses on the utility of single-cell methods to access genetic material of uncultivated taxa of interest. One such … that are from candidate phyla, major branches in the phylogenetic tree without cultivated representatives. The “Great … Phylogenetic diversity estimates show that the gap between …

… bit more into fungi and learning the differences of all the genetic differences and then expanded on on that knowledge … has been doing work in secondary metabolism. The very first CSP I ever worked on back in Brad’s lab, we talked about it … was the Salinispora genome project. And that was a JGI CSP project. They sequenced that genome for us at a time …

… and BiG-SLiCE, and now the BiG-FAM database of biosynthetic gene cluster families. And he tells us about forthcoming … a nice example of going from a whole community with many microbes, hundreds of gene clusters, and then being able to … that the expression of these gene clusters play in these interactions. But also things like trying to predict at …

… advanced sequencing technologies to decode the genomes of microbes in their natural environments. This work … along with their associated viruses and mobile genetic elements. Beyond exploring and characterizing … ecosystems.  By studying microbial communities and their interactions, the Program aims to unlock the fundamental …

… Sure. So my lab has really converged on the study of host-microbe chemistry. And the interactions– As much as we incorporate loads of different … products is that we don’t know what all the biosynthetic gene clusters look like.  DAN: For sure.  MARCY: We have so …

… my undergraduate in microbiology and then PhD in microbial genetics in the UK. And came across to the US for a couple … NIGEL MOUNCEY: Yeah, so we put out a strategic plan in 2018. And in building that plan, we thought about secondary … But they really span our core science programs which are microbes, and fungi, and algae plants, synthetic biology. …

… and characterize genomic information from uncultivated microbes and viruses. We develop computational approaches to … This process enables our users to explore the genetic makeup of microbial communities, shedding light on … genomes from metagenomes, we gain insights into microbial interactions, evolution, and adaptation, ultimately …

… genomics existed. This is before we’re even thinking of genes and connecting genes to molecules, which is something … systems. No one was, at that time, really working with microbes from the ocean. So I felt there was a wonderful … JGI projects over the years starting with, you know, the CSP that we did and then leading up to today to some …

… The CSP and FICUS calls are open to both domestic and … from any institution type and at any career stage. Generally, most users are able to work with Berkeley Lab.  … Agreement must be signed before work can begin, and all CSP proposals are subject to JGI policies on Data Release …

… America brought to the UK? ROGER:  Yeah, it’s difficult to generalize, of course, but I felt overall that the British … my perspective, JGI has a large database of biosynthetic gene clusters and biosynthetic gene cluster fragments, and all kinds of other crazy things. …

… and he has a project with the JGI to synthesize the genes for and explore the chemistry of quorum sensing … then we were using these probes to look at host pathogen interactions mostly with like enteric bacteria. And I really … ecology community to be able to better predict how their microbes are interacting with each other from sequence …