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… about something I can kind of see like the squid and the bacteria and how the chemistry is going back and forth … your opinion then on bioprospecting in sparse nutrient environments versus the tropics? Because like you say there is … on increasing computational skills among biologists JGI CSP Proposal: Metagenomic mining of natural product …

… into the secondary metabolism of some more novel marine bacteria. You know, I first met Bill as a postdoc working … a program that involves researching the local marine environment. I went out and picked up marine plants, I picked … now of about 17,000 organisms we’ve isolated from sediments, bottom mud, all over the world. We created ways …

… cell types and associated organisms, including fungal and bacterial symbionts, detrimental microbial pathogens, and … and spatial transcriptomics to profile the plant/environmental interface. We are using these methods to … Interactions … Single-cell characterization of plant/environmental responses … Selected Publications … Research Team …

… molecule of water. DAN UDWARY: Mhm. So oxygenases, they’re oxidizing other molecules. ALISON NARAYAN: Correct. Correct. … flavors. So non-heme enzymes, it just means that they need iron. DAN UDWARY: Right. ALISON NARAYAN: They have iron in their active site, but it’s not in the form of a …

… like that. And let’s say it eventually ends up in the sediment, there’s no oxygen and that a lot of that carbon … unless there’s enough of them around to affect their environment. So I think the classical example yeah, is biofilm … favorite bacterial community. For us, it’s these methane oxidizing bacterial communities that we like to look through …

… pathways, which led her to a successfully funded JGI CSP project. And we also got to talk about work at her … But what was really interesting is when I started my lab in 2018, several papers came out right in a row all about this … --really high. DAN: Yeah. Graduate school is a pressured environment, right? JACKIE: Yes. DAN: And so there's always-- …

… to explore the vast and diverse world of microbes. Studying bacteria and archaea, including those associated with … These insights are crucial for addressing key environmental challenges, such as improving soil health, carbon … populations of bacteria and archaea in their natural environments using single cell approaches. This includes …

… in. All proposals must be written in English. … The CSP and FICUS calls are open to both domestic and … Agreement must be signed before work can begin, and all CSP proposals are subject to JGI policies on Data Release and Publication .   Except for applicants to the CSP New Investigator call, investigators may have existing …

… to the user and no granting of funds.   Proposal Call FICUS CSP Large Scale CSP New Investigator CSP Functional Genomics Status CLOSED CLOSED ONGOING ONGOING …

… they spread, why do they spread in a certain way from one bacteria to another, how do they change then, and why are … which is still hard to do. We are mining a lot of environments to see where are environments that have the most … But we also have, in collaboration with other people, lake sediments. We have microbiomes from different organisms, …

… be fun to be able to look at a cousin organism from marine sediments. And so JGI was interested in that and they worked … of the most notorious toxins there are in the marine environment. And it was that year that the Pacific Northwest … JGI projects over the years starting with, you know, the CSP that we did and then leading up to today to some …

… on an old rum still, which– you’ve got this very sugary environment. It’s a compound that clearly kills things that … NIGEL MOUNCEY: Yeah, so we put out a strategic plan in 2018. And in building that plan, we thought about secondary … An Age of CRAGE: Advances in Rapidly Engineering Non-model Bacteria Check out the agenda for the JGI’s 2021 Annual …