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Natural Prodcast Episode 4: Nancy Keller
… I wanted to go into international agriculture. I had really changed my mind. I was thinking of medical school first, but … got my start.   DAN: A lot of the natural products field is based on, you know, in bacterial investigations. You’ve … this, Daniel, there’s a lot of worry about that with the climate change that’s occurring. There’s been a lot of …
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Natural Prodcast Episode 11: Marnix Medema
… Dan Udwary: You’re listening to the Department of Energy Joint Genome Institute’s Natural Prodcast, a … like BiG-scape and BiG-SLiCE, and now the BiG-FAM database of biosynthetic gene cluster families. And he tells us … a challenge, and there is actually some cases where we’ve changed things in antiSMASH because, well, some things were …
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DNA Synthesis Program
… The JGI’s DNA Synthesis Program supports a wide range of projects, from single-gene synthesis to the synthesis of entire chromosomes, advancing the development of … on addressing critical energy and environmental challenges. Through innovative research in synthetic biology, the …
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How to Submit Sequencing Samples
… Below is a brief description of the process needed to prepare and ship samples for … sample QC requirements and protocols Obtaining DNA and RNA of suitable quantity and quality has been the rate-limiting … for sample collection and storage (from PacBio) Best practices for High Molecular Weight DNA extraction and quality …
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Polar Phytoplankton Need Zinc to Cope with the Cold
… Antarctic algae need their vitamins; zinc fuels some of their most important functions. Even in the chilly waters … inhabit their frigid environment, Mock pointed out that as climate change warms polar waters, changes in trace metal … sequencing and computational analysis that enable systems-based scientific approaches to these challenges.  DOE’s …
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Natural Prodcast Episode 5: Brad Moore
… DAN: You’re listening to the US Department of Energy Joint Genome Institute’s “Natural Prodcast,” a … a relatively small genome, about five and a half million base pairs. It was not linear, like Streptomyces , but … the group has, I guess… Maybe my philosophy has sort of changed over the years. And I think maybe over the last 10 …
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New Lineages of Life Group
… research is focused on the discovery and characterization of novel bacterial, archaeal and eukaryotic microbes and … to identify new divergent lineages and expand the Tree of Life. We then investigate the coding potential to find … Exploring the fascinating world of giant viruses, which challenge our understanding of viral …
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DOE Metrics
… FY 2026 DOE Metrics Sequencing Quarter Total Bases (Trillions) Operating Hours Goal  Actual Total*   Actual % of Goal   Goal (hours)**   Actual Total   Actual % Goal   FY … PacBio sequencing platforms. **Operating Hours target is based on 98% of the total available hours.   FY 2025 DOE …
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Calculating the Costs of Multiple Switchgrass Gene Copies
… for habitat restoration and as a feedstock for biomass-based biofuel production. As seen with many commonly … the 4X and 8X cytotypes diverge in their response to climate variations between the common gardens, indicating a … mediated the response of switchgrass to past climate change will provide unprecedented insight into the …
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Natural Prodcast Episode 8: Eric Schmidt
… DAN: You’re listening to the US Department of Energy Joint Genome Institute’s “Natural Prodcast,” a … and it turns out it’s pretty engineerable – you can change the protein to some extent, and end up with a … And you can find them everywhere. They’re at the base of the animal kingdom, in terms of evolution. Because …
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Natural Prodcast Episode 1: The Primer, Part 1
… DAN: You’re listening to the US Department of Energy Joint Genome Institute’s “Natural Prodcast,” a … see things that maybe aren’t real, and so it’s thought that based on historical records and weather recordings of the … slash natural product. And, can you just use that interchangeably? DAN: Sure. I mean, maybe — First, we can say, if …
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Natural Prodcast Episode 13: Francisco Barona Goméz
… DAN UDWARY: You’re listening to the Department of Energy Joint Genome Institute’s Natural Prodcast– a … is, then this is the podcast for you. A lot of this is based on a really great paper that came out in 2020 where … problems with editing the recording. But I recently changed the audio editing suite I use which had some nice …
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