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… off today with my interview with the Director of the Joint Genome Institute and head of the Secondary Metabolites … some sigma factor work and anti-sigma factors. in my past life.  DAN: Yeah, I didn’t really appreciate that that’s … core science programs which are microbes, and fungi, and algae plants, synthetic biology. And so we have, I think, …

… 2014), unearthing hundreds of thousands of new viral genomes and their predicted hosts (Nature 2016, Science … of bacterial and archaeal isolates expand coverage of the tree of life.  Nature Biotechnology  35(7):676-683 Schulz … Eloe-Fadrosh EA, et al. (2016) Metagenomics uncovers gaps in amplicon-based detection of microbial diversity.  …

… food, medicine, and bioenergy crops. But most available genomes are from narrow swaths of the plant tree of life. One project aims to change that. …

… … DAN: You’re listening to the US Department of Energy Joint Genome Institute’s “Natural Prodcast,” a podcast about the … for which, by genome sequencing, we know they are more proliferative than the enediyne we have isolated to date by the … taxol, for example. If you say isolate compound from the trees – if you’re cutting the trees, it takes years to …

… of secondary metabolites across bacteria, fungi, algae and plants. These molecules, which are not essential … factors and determine their binding sites across multiple genomes. Computational prediction of heterologous … biosynthetic gene clusters (BGCs) across all kingdoms of life. Tools are provided to display annotation data from …

… … DAN: You’re listening to the US Department of Energy Joint Genome Institute’s “Natural Prodcast,” a podcast about the … lot about chemistry. And he has been a good friend in my life. And so I’m very happy to be here and have Eric sitting … grade list of goals in life: on that list are being a marine biologist and being a chemist, and it’s actually …

… … DAN: You’re listening to the US Department of Energy Joint Genome Institute’s “Natural Prodcast,” a podcast about the … But where taxol comes from is, from the bark of the yew tree, is where it was originally discovered. And so that … might be as critical or it might be as big a part of its life as metabolizing sugars, but it’s something that we …

The Metagenome Program uses advanced sequencing technologies to decode the genomes of microbes in their natural environments. This work … of all publicly available genomes from three domains of life, in a uniquely integrated context.  … The IMG/VR system …

Research in the Eloe-Fadrosh group focuses on using genome-resolved metagenomic approaches to identify and … for stable isotope probing metagenomics . mSystems , e01280-22. 10.1128/msystems.01280-22 Clum, A. et al. (2021)  … Emiley A. et al. (2016)  Metagenomics uncovers gaps in amplicon-based detection of microbial diversity . …

So I was always an outdoorsy kid – I was often found in a tree or covered in dirt playing with my dog in the yard. But … it’s not that easy. There are still not that many plant genomes, certainly nowhere close to bacterial kinds of … on plant natural products. Rich, rich in bacterial and marine stuff. So we need more people annotating. It will …

… the ever-changing demands of our users. … Download plant, algal, fungal and microbial genomes and metagenomes — top-quality genomic data, open to … of all publicly available genomes from three domains of life, in a uniquely integrated context. IMG/M provides tools …

Breaking Bad, I guess. But no, you trained me in how to genome mine, so thank you for that. And you had to put up … just not enough time and money. I mean, we have a huge marine fungal project in collaboration with Bill Fenical at … there a way to do that? DAN UDWARY: Well, so there’s good news and bad news on that. So one of the things that we’re …