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… of Natural Prodcast. A little bit of a bonus episode, since I’m off schedule, but this is an important one that … Doering and Bryce Foster and too many others to name at JGI for the last two years or so. SMC is now released and ready … are familiar with JGI’s IMG data portal , the Integrated Microbial Genomics, there was a subsection of that called …

… approaches to identify and characterize genomic information from uncultivated microbes and viruses. We develop … of metagenomes for signatures of viruses and novel microbial lineages, and reconstruct metabolic properties … Our aim is to more fully capture microbial and viral diversity, leading to a better understanding of microbial …

… bacterial, archaeal and eukaryotic microbes and viruses in environmental sequence data. We use multi-omics (metagenomics, metatranscriptomics, single cell genomics and phylogenomics) and machine learning to identify new divergent lineages and expand … insights into viral evolution and complexity, and encode for a treasure trove full of novel genes ready to be tapped …

… The JGI’s Microbial Program focuses on using cutting-edge sequencing, annotation and analysis … inter-organismal interactions. These insights are crucial for addressing key environmental challenges, such as … and inter-organismal interactions, which are critical for advancing sustainable solutions in agriculture, energy …

… DAN UDWARY: You’re listening to the Department of Energy Joint Genome Institute’s … Mexico, and an incredibly bright guy who’s been thinking for a long time about the evolution and natural products … is that you could, therefore, expect a lot of chemical diversity. So many compounds will fulfill the same function. …

… of secondary metabolism.  DAN: Hello, and welcome back for Episode 7 of the Natural Prodcast. It’s been about a … the enediyne we have isolated to date by the traditional methods. But more importantly, we hope through enediyne that … genomic revolution, to me, as a natural part chemist for microbial natural product, is that I love microbial natural …

… DAN: Hey, everybody. Welcome back for another episode of Natural Prodcast. Right now I’m … And one would envision that microorganisms have evolved multiple variations of these compounds. And so if you’re … JGI is we identified using some different computational methods a bunch of different syntheses that make quorum …

… of secondary metabolism.  DAN: Hey there and welcome back for Episode 8 of Natural Prodcast. This week, we have our … with animal metabolism itself, and it’s really amazing what diversity there is in animals. I think, even despite the … them. And so, I spent a number of years trying various methods, back in the old days, to figure out how they’re …

… Plants are complex organisms that harbor a fantastic diversity of cell types and associated organisms, including fungal and bacterial symbionts, detrimental microbial pathogens, and associated viruses that all … strain engineering and experimental characterization methods, in addition to bioinformatics tools to elucidate …

… strengthens -omics technologies at the JGI by identifying the actual molecules present in an environment that … of new molecules and pathways. The JGI Metabolomics Platform delivers rich metabolite profiles from diverse … liquid chromatography mass spectrometry (LC-MS) based methods in combination with advanced computational analysis. …

… DAN: Welcome back for episode 9 of Natural Prodcast. This week, Alison and I … to try and create an open source database of all known microbial natural products. So if you think about natural … spectrometry hardware, software, new developments in NMR methods, ultra fast methods for acquisition. Things like …

… genetic elements. Beyond exploring and characterizing microbial diversity, work in the Metagenome Program uses several … diversity and metabolic potential, with implications for energy production, environmental sustainability, and … linked to custom interfaces and visualization tools for user analysis. Additionally, the Program works to link …