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… world’s potential to address global challenges by exploring plants’ role in capturing carbon, detoxifying soils, … to regulate Earth's carbon balance, to exploring the genetic basis of how plants have naturally adapted to varied … climate and soil conditions around the globe to identify genes to improve our domesticated species.  The program …

… & Algal Program explores the vast diversity of fungi and algae to unlock their potential for bioenergy, environmental … on large-scale sequencing efforts that survey the vast phylogenetic and ecological diversity of fungi and algae, … functioning — particularly in their roles associated with plants (mycorrhizae, endophytes, growth promoters, or …

… of secondary metabolites across bacteria, fungi, algae and plants. These molecules, which are not essential for … conditions, with only a small portion of the biosynthetic gene clusters (BGCs) being expressed. The program works to … platforms, tools and data for deciphering regulatory networks, and refining experimental approaches to explore …

… metabolomics fuels the discovery  of novel metabolites, genes, and proteins. It also enables exploration of energy … biogeochemical processes, development of high performance plants and microbes, and understanding microbiome … and their hosts on ecosystems.   Environmental molecular network:   ENVnet   is a comprehensive, mass …

… my undergraduate in microbiology and then PhD in microbial genetics in the UK. And came across to the US for a couple … . And that got me really interested in microbial gene regulation and some pathways. And I thought I’d take an … to society really does give you the chance to build those networks of folks that you may not normally run into or …

… bioprospecting vs biopiracy, early stage drug discovery in general, and a possible data-driven future for plant natural … from the microbes in that soil, there are now international regulations that provide a structure for ensuring that the … resources, but they don’t necessarily have the support network, the equipment, the facilities to really apply the …

… talk about Antarctica, and we want to talk about molecular networking, because I really enjoyed the review that you … I was imagining some massive contraption for amplifying genes. I wasn’t really sure what actinobacteria were. Dan … transcriptomics, metabolomics, and natural products in plants, fungi, and microorganisms. If you want to …

… work, including bacterial quorum sensing and its effects on regulation of natural product biosynthetic pathways, which … oftentimes will bind to receptors within biosynthetic gene clusters. Specifically, these are Tet repressors that … are unknown. And so we've done the sequence similallity network analysis where we look for other receptors with …

Plants are complex organisms that harbor a fantastic … single-cell and spatial transcriptomics barcode-based genetics (RB-TnSeq), and computational genomics to better … strains, whereby they can modulate host metabolism, gene expression and phenotype. We have recently identified …

… and BiG-SLiCE, and now the BiG-FAM database of biosynthetic gene cluster families. And he tells us about forthcoming … time. And we used a technology called “sequence similarity networking” of gene clusters, where you would make a network … bacteria living on and inside the roots are protecting the plants against pathogens. So usually fungal or oomycete …

… the active site of an enzyme. So there is no promiscuity, generally speaking, in primary metabolism. Nevertheless, … evolutionary forces are shaping each part of the metabolic network in each specific organism. Really, what matters is … to think of these things as the organisms would turn the regulation off, rather than negatively get rid of the genes …