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… metabolomics fuels the discovery  of novel metabolites, genes, and proteins. It also enables exploration of energy … JGI scientists are able to link metabolic activity with gene expression, providing deeper insights into functional …

… to regulate Earth's carbon balance, to exploring the genetic basis of how plants have naturally adapted to varied … climate and soil conditions around the globe to identify genes to improve our domesticated species.  The program … Centers. The  Plant Gene Atlas initiative develops gene expression catalogs across JGI Plant Flagship …

… conditions, with only a small portion of the biosynthetic gene clusters (BGCs) being expressed. The program works to … uncover these hidden biochemical resources by exploring the genetic pathways responsible for their synthesis. The … pathway analysis, optimization of cell- and cell free-based expression platforms, tools and data for deciphering …

It was unpublished at that point. But people would push out gene clusters maybe once a month at most. Maybe twice a year, a full gene cluster would come out. And it was a very exciting … if you want– if you really want to, you can do heterologous expression. You can do homologous expression techniques and …

… and BiG-SLiCE, and now the BiG-FAM database of biosynthetic gene cluster families. And he tells us about forthcoming … Island. And was working on a natural products/biosynthetic gene cluster database, and a tool for predicting natural … was a proposal on synthetic biology of engineering gene expression in bacteria – however, the professor was actually …

… and he has a project with the JGI to synthesize the genes for and explore the chemistry of quorum sensing … And Alison has done a really nice job of providing that general scientific audience whereas now I’m sitting here … of these or any organisms. So developing good heterologous expression hosts like maybe in many fields now like in …

The focus of this group, in recent years, has been to bring generalizable technologies to bacteria, yeasts and algae previously with little to no genetic tools enabling heterologous expression and functional exploration.  The developed …

… my undergraduate in microbiology and then PhD in microbial genetics in the UK. And came across to the US for a couple … spheroides . And that got me really interested in microbial gene regulation and some pathways. And I thought I’d take an … explore the regulation of biosynthetic gene cluster expression in organisms. And that’s led by Hiroshi Otani …

… oftentimes will bind to receptors within biosynthetic gene clusters. Specifically, these are Tet repressors that oftentimes turn off these biosynthetic gene clusters. And so we've been really interested in trying … that you can turn on the natural product, say clusters or expression systems so that-- BETSY PARKINSON: Exactly. DAN: …

Fine-tuning metabolic gene expression helps identify variants in yeast genes. The Science Scientists have developed a more nuanced …