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…   Our Sequencing Technologies Group is well-integrated across JGI departments to ensure a robust … — and further advancing sequence applications, single cell genomics, biodesign, and metabolomics capabilities.    … An assay used for profiling transcription factor binding sites across entire …

… the soluble components of lysed cells. By separating the production of enzymes (during growth) and the biochemical … can push more of the carbon that we feed into a product molecule and so we’re able to make the same amount of a … grams per Liter-hour in a system optimized for developing small-scale prototypes. Additionally, the team also used a …

… Do metabolic pathways from engineered yeasts still work in cell-free environments? … can push more of the carbon that we feed into a product molecule and so we’re able to make the same amount of a … grams per Liter-hour in a system optimized for developing small-scale prototypes. Additionally, the team also used a …

… Research in the Woyke laboratory focuses on the utility of single-cell methods to access genetic material of uncultivated taxa … uncultivated Bacteria and Archaea has steadily been widening since 2005. This gap is also reflected in the strongly … belong to only three phyla. The Woyke group uses single-cell sequencing as a means to begin filling this gap. A …

… back to a new session of Natural Prodcast. I’ve got two things I wanted to tell you about in this introduction. First … analoging of some really complex bioactive natural product molecules. It’s a wide ranging conversation, and we could … that need to defend each other or subdue one another with small molecules. DAN UDWARY: Antibiotics, yeah, to fight …

… The JGI has diverse capabilities in: DNA and RNA sequencing, Sample and library preparation, Biodesign and pathway engineering Mass spectrometry based metabolomics Below is a … Synthesis Constructs <5kb in size Single gene or multiple small genes assembled to less than 5kb in length, cloned …

… bond. And then you know, the rest of a natural product molecule around that. That’s sort of a semi-stable … toxic molecules, and that human beings know, today, for small molecules. So they’re in the picomolar range. ALISON: … are the biological version of the catalyst to catalyze the production of the natural product. So that was my PhD study, …

… into piloting and to finally get things into commercial production. So the full stretch of things. Full stretch all … big pathogen of wheat in cereal crops in Europe. And the molecule is derived from a natural product called UK2A that … like I said. And I’m part of that. It’s a few of us now, small little group. What’s your vision for us in our group?  …

… you need to go back to your extract and try to purify the molecule that’s causing that test to be successful. Right? … of enzymes and sometimes those are referred to as “small molecules” because proteins are actually molecules … gene that’s likely to be involved in secondary metabolism – production, say of a certain molecule. If you can find one …

… The CSP New Investigator Call is for investigators and research … will provide pilot data to assess feasibility of a novel approach or form the foundation for a large-scale CSP … synthesis, metabolomics and analysis will be provided for free to the PI by the Department of Energy’s funding of the …

… Synthesis Program supports a wide range of projects, from single-gene synthesis to the synthesis of entire chromosomes, advancing the development of biofuels, biochemicals and other bioenergy solutions.  The program has been a pioneering effort in functional genomics since 2012, with a focus …

… is Professor Cassandra Quave from Emory University, with joint appointments in the School of Medicine and College of … heard of anthropology. This is– I grew up in a very rural, small town. We didn’t have AP or IB courses or any of these … And so I think that there are really interesting small molecules in nature that are just waiting to be found. …