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Genome sequence of hybrid Vibrio cholerae O1 MJ-1236, B-33, and CIRS101 and comparative genomics with V. cholerae

Published in:

J Bacteriol 192(13) , 3524-33 (Jul 2010)

Author(s):

Grim, C. J., Hasan, N. A., Taviani, E., Haley, B., Chun, J., Brettin, T. S., Bruce, D. C., Detter, J. C., Han, C. S., Chertkov, O., Challacombe, J., Huq, A., Nair, G. B., Colwell, R. R.

DOI:

10.1128/JB.00040-10

Abstract:

The genomes of Vibrio cholerae O1 Matlab variant MJ-1236, Mozambique O1 El Tor variant B33, and altered O1 El Tor CIRS101 were sequenced. All three strains were found to belong to the phylocore group 1 clade of V. cholerae, which includes the 7th-pandemic O1 El Tor and serogroup O139 isolates, despite displaying certain characteristics of the classical biotype. All three strains were found to harbor a hybrid variant of CTXPhi and an integrative conjugative element (ICE), leading to their establishment as successful clinical clones and the displacement of prototypical O1 El Tor. The absence of strain- and group-specific genomic islands, some of which appear to be prophages and phage-like elements, seems to be the most likely factor in the recent establishment of dominance of V. cholerae CIRS101 over the other two hybrid strains.

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