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… focuses on the utility of single-cell methods to access genetic material of uncultivated taxa of interest. One such … that are from candidate phyla, major branches in the phylogenetic tree without cultivated representatives. The “Great … highlights our skewed understanding of microbial metabolism towards a minority of cultivated bacteria, still persists …

… through end-to-end automation — and further advancing sequence applications, single cell genomics, DNA synthesis, … [QA/QC]), large-scale liquid handling automation, and sequence analysis. … access to cutting-edge cell sorting, DNA amplification, and sequence analysis to recover the genomes of uncultivated …

… and eukaryotic microbes and viruses in environmental sequence data. We use multi-omics (metagenomics, … and expand the Tree of Life. We then investigate the coding potential to find novel functions that may impact microbiome … complexity, and encode for a treasure trove full of novel genes ready to be tapped for downstream applications. …

… bioprospecting vs biopiracy, early stage drug discovery in general, and a possible data-driven future for plant natural … culture-disconnected. Like we’ll take some soil samples and sequence all the bugs out of that or whatever. And so I was … and not necessarily in medicines. [CHUCKLES] Selfishly, what can or should we be doing to help the plant …

… When submitting sequences to the JGI DNA Synthesis program, please include … Sequence files for all constructs should be emailed to  Miranda Harmon-Smith, Synthetic Biology Project Manager . … several easy-to-use open source tools for converting DNA sequence files into well-formed GenBank files. ApE is an …

… the JGI’s Plant Program delves into the natural world’s potential to address global challenges by exploring plants’ … carbon, detoxifying soils, interacting with other organisms, and adapting to environmental changes. The program lays … plant growth and productivity. These insights have the potential to inform strategies that improve agricultural …

… of terrestrial biogeochemical cycling and inter-organismal interactions. These insights are crucial for addressing … include terrestrial biogeochemical cycling and inter-organismal interactions, which are critical for advancing … energy and ecosystem management. The program aims to generate high-quality genomic datasets, particularly for …

… as part of the International Biodiversity Drug Discovery consortium doing natural products isolation/structure … and to go through all of these abstracts and titles and to fish out data about new molecules that have been found. And … And that’s been followed by developments in pulse sequences and improvements in the ways in which you acquire …

… sequencing products below. In addition, JGI will submit raw sequence data to  SRA at NCBI once the standard analysis is … result certain products have been  discontinued , including smRNA, bisulfite sequencing, and ChIP-seq. … in length, cloned into vector of choice Glycerol stock of sequence verified clone 102/NA DNA Synthesis Constructs …

… the vast diversity of fungi and algae to unlock their potential for bioenergy, environmental sustainability, and … By sequencing and analyzing the genomes of these organisms, the program investigates the biological mechanisms that … This research helps translate their genomic potential into practical applications, including sustainable …

… The JGI’s Metabolomics Program works to uncover the roles of small molecules in biological systems, linking them with … data to enhance our understanding of genome science, organisms, and ecosystems at the molecular level. Integrating … metabolomics fuels the discovery  of novel metabolites, genes, and proteins. It also enables exploration of energy …

… growth, provide critical advantages to the organisms producing them, and are often involved in defense, … diversity within secondary metabolites, expanding their potential applications in the bioeconomy including biofuels, … conditions, with only a small portion of the biosynthetic gene clusters (BGCs) being expressed. The program works to …