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… now?  MARCY: Sure. So my lab has really converged on the study of host-microbe chemistry. And the interactions– As … that the squid is one– is we work on a lot of host-microbe symbiosis at this point. But the squid is probably the most … you try to tackle that? Would you do that through metabolomics or sequence or both or–?  MARCY: So we do so much more …

… influenced by microbial partners. We use a variety of genomics-powered tools to study this complexity, including single-cell and spatial transcriptomics barcode-based genetics (RB-TnSeq), and computational …

The JGI’s Metabolomics Program works to uncover the roles of small molecules … and ecosystems at the molecular level. Integrating genomics with metabolomics fuels the discovery  of novel … health, and bioenergy development. … EcoFABs:  For studying microbe-host (or plant-microbiome) interactions …

… a revolution brought on by rapid developments in genomics and other omics technologies.  The exponential growth of DNA … Unraveling the functional dark matter through global metagenomics. Nature . 622(7983):594-602. Camargo AP. et al. (2023) …

…   Gain access to omics technologies generating community data at zero cost — …

… on the application of  function-driven single-cell genomics . Here, single cells are characterized and selected as … Chris Rinke: Research Officer, Australian Centre for Ecogenomics Patrick Schwientek: Cofounder & CTO, Oralta … Schulz … Amann R., Bergin C., Ruehland C., Rubin E.M. & Dubilier, N. Symbiosis insights through metagenomic analysis of a …

The CSP Functional Genomics call is to enable users to perform state-of-the-art functional genomics research and to help them translate genomic … emphasis is on projects leveraging JGI’s DNA synthesis and ‘omics capabilities to enhance understanding of gene and …

… kept looking for open jobs that said, we want a chemist to study the ocean. And I didn’t find a single job … to do something completely new. And that is to begin to study the organic chemistry of life in the sea. And he … all over the world and bringing samples into the lab for study. DAN UDWARY: Where were you on the timing of that …

… just now switching from intermicrobial interactions, studying intermicrobial interactions by imaging interactions … And we can use our fancy multiplexed activity metabolomics method to tell us what’s active, which peak is active … enzymology to natural product biosynthesis to genomics to directed evolution– but it’s just the– it really is …

Metabolomics strengthens -omics technologies at the JGI by identifying the actual … system behavior.  Through this identification, metabolomics enables functional genome annotation, improves … the discovery of new molecules and pathways. The JGI Metabolomics Platform delivers rich metabolite profiles from …

And he tells us about forthcoming efforts in paired-omics data sets and seeking to interpret function from BGCs. … what was this bacterium, and why did your group want to study it? Marnix Medema: You mean the PhD project that I … of hooks into IMG’s data. IMG being Integrated Microbial Genomics at JGI, a large data set of bacterial genomes. And so …