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… metabolism. Hey everybody, this is Dan with episode 13 of National Prodcast. This continues our little section … features of the compound. For example, lipids– doesn’t matter if it has one extra carbon or two or one less, at the … move a little bit away from that to try to unmask chemical dark matter. And the idea behind this is that, if we …

… DAN: Hello, everyone, and Welcome back for Episode 14 of Natural Prodcast . There’s been a lot going on, so I … never forced it on me, but we always had these scientific news magazines lying around at home. And I would just pick … looking at emails and I just saw this pop up. And saw a C&E News job little box and I thought, wow, this would be …

… global diversity of alternative genetic codes (Science 2014), unearthing hundreds of thousands of new viral genomes … host-virus interactions, the exploration of the functional dark matter as well as the development of novel methods to enable … Pavlopoulos GA et al. (2023) Unraveling the functional dark matter through global metagenomics. Nature . …

… of uncultivated microbial lineages. Charting viral ‘dark matter’:   Viruses are abundant in the biosphere and …

… like a nice summer day in Seattle I think this was like 2013 or 2014. And antiSMASH — I know you’ve interviewed Marnix … or it could be a whole grad student thesis to synthesize a 13C-labeled version of your compound. So people have been … Stable Isotopic Labeling . ACS Chem Biol. 2021 Aug 20;16(8):1332-1338. doi: 10.1021/acschembio.1c00329. …

… E.M. Stop codon reassignments in the wild. Science 344, 909-13 (2014). Rinke C., Schwientek P., Sczyrba A., Ivanova … into the phylogeny and coding potential of microbial dark matter. Nature 499, 431-7 (2013). Hess M., Sczyrba A., Egan …

… know nothing about biology. Biology hates us. It’s a little dark, but. [laughs] DAN UDWARY: Yep. ALISON TAKEMURA: It’s … Nature  Biotechnology . 2020 Nov 9. doi: 10.1038/s41587-020-0718-6) DAN UDWARY: Yeah, I think that might be a good … can be applied to secondary metabolism almost always, no matter what that is. Almost always. How do people do that? I …

… that’s really popped up at funding agencies and the popular news recently because a lot of soldiers in the Iraq and … that on that timescale of the earth that geography doesn’t matter as much. But, you know, there’s clearly some, you … mosaic theory. MARC: So how quick, and how much geography matters, is going to be a function of what the molecules are …

… then the organisms all around us or the, you know, the bio matter that’s around us now? Brad: Yeah, I mean, petroleum … still with us? Brad:  Unfortunately, not. We lost him about 13 years ago. So, I wish he was still with us because I know …