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… is like, what’s your origin story in natural products? Why are you doing this? JACLYN WINTER: I’ll kind of go back … have an E. coli strain that we’ve been working on that we sequenced the genome. And it has 17 resistant genes on a … seems to be a new structure, and the microorganisms are novel. I mean, we have Streptomyces , but they’re new …

… is focused on the discovery and characterization of novel bacterial, archaeal and eukaryotic microbes and viruses in environmental sequence data. We use multi-omics (metagenomics, … of Life. We then investigate the coding potential to find novel functions that may impact microbiome structure and …

… through end-to-end automation — and further advancing sequence applications, single cell genomics, biodesign, and … [QA/QC]), large-scale liquid handling automation, and sequence analysis. … access to cutting-edge cell sorting, DNA amplification, and sequence analysis to recover the genomes of uncultivated …

… When submitting sequences to the JGI DNA Synthesis program, please include … Sequence files for all constructs should be emailed to  … several easy-to-use open source tools for converting DNA sequence files into well-formed GenBank files. ApE is an …

… to kill cells. So it’s really remarkable in terms of a novel mechanism, how a small molecule can kill. So that … the paradigm of how to discover natural products. So, why I’m very excited to be working with Dan, you, with the … develop enabling technologies. ie how to translate the ATGC sequence into discrete small molecules. So, Dan, I’m very …

… more than 50,000 genomes that we derived from meta-genome sequences. As always, you’ll find transcripts and show notes … for us– what organisms people use for genome mining, why it’s called genome mining, how the biosynthetic gene … machine learning really would help distinguish and predict novel gene clusters. DAN UDWARY: Yeah, it certainly could. …

… approaches to identify and characterize genomic information from uncultivated microbes and viruses. We develop … thousands of metagenomes for signatures of viruses and novel microbial lineages, and reconstruct metabolic … Our research focuses on the assembly of metagenomic sequence data into microbial genomes, which is of …

… Prodcast. And it’s our conversation with Nadine Ziemert from the University of Tübingen in Germany. Like me, she’s a … there are any kind of dated references to the news, that’s why. But it was a really fun conversation. And I think … it would work, but we actually found fosmids. And we sequenced the whole fosmid at the time with Sanger …

… learned a lot so much history from this conversation about why the ocean was basically unexplored until the 70s, and … an exploration into the secondary metabolism of some more novel marine bacteria. You know, I first met Bill as a … forward to seeing the data when it finally gets off the sequencers. The pandemic has obviously slowed JGI down a …

… JGI serves more than 2,500 users that predominately come from the public sector: academic and government institutions … among members that catalyze data flows and promote novel data applications. As a large-scale data generator, … Our metabolomics platform delivers rich metabolite profiles from diverse biological and environmental samples by using …

… we have our conversation with Professor Alison Narayan, from the University of Michigan. I hope she’ll accept this … enzymes are, right? ALISON NARAYAN: Yes, and so that’s why I don’t like that sentence. I think that sometimes, we … association that might help? Like, if you have an unknown sequence or new flavin monooxygenases, you could say, oh …

… prefers to be known among friends in natural products. He’s from Langebio in Irapuato, Mexico, and an incredibly bright … least, talk to us, first about my definitions of things and why I am wrong, and also talk about some of the great … to approach it is more related to what JGI does, which is sequence genomes. And we just published last year in the …