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… Studying microorganisms that thrive in Earth's most extreme environments: We study genomic innovation that allowed microbes to adapt to … sequence data, including microbial phenotype along the symbiosis continuum … Microbial Symbiosis …

… now?  MARCY: Sure. So my lab has really converged on the study of host-microbe chemistry. And the interactions– As … Marcy. So I was wondering, how did you get interested in studying natural products?  MARCY: That is a great question … that the squid is one– is we work on a lot of host-microbe symbiosis at this point. But the squid is probably the most …

… the same sorts of things. And then, bacteria often live in symbiosis with plants and might actually be producing … like, and then you could characterize it. The classical study that demonstrated this is Challis et al, Chemistry and …

… Amann R., Bergin C., Ruehland C., Rubin E.M. & Dubilier, N. Symbiosis insights through metagenomic analysis of a …

… know, do your organic reaction and see if it smells like a pine tree. Like there’s no cookie cutter reactions here, …

… just now switching from intermicrobial interactions, studying intermicrobial interactions by imaging interactions … looked at the grant applications for the last 40 years for studying biosynthetic pathways, all of them said that a … You can make new molecules. And you could– and you could study things that might be difficult to write a grant on …

… kept looking for open jobs that said, we want a chemist to study the ocean. And I didn’t find a single job … to do something completely new. And that is to begin to study the organic chemistry of life in the sea. And he … all over the world and bringing samples into the lab for study. DAN UDWARY: Where were you on the timing of that …

… ALISON TAKEMURA: So Nadine, what got you interested in studying natural products? NADINE ZIEMERT: Like almost … really then helps you to get back to, oh, why am I actually studying that question? DAN UDWARY: We know each other I … that this was a perfect fit for what I wanted to do. Also studying evolution and the role of the secondary …

… to use it, it’s got to be surgically placed into your spine into your – intrathecally – and then you tune up the … was one where there was a kind of a good well defined symbiosis. The compounds found in those animals were really … crack this case, then that would open up our field to other study. And so it was kind of an early example, to try to …

… plant natural products, and what really fascinated me – the pinene – if you go to the forest, you have this very … fresh scent of the fresh air of the forest. So the alpha-pinene… Just [think about] your hands: there’s a right hand … the production of the natural product. So that was my PhD study, and then towards the end of my PhD study, then …