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… DAN: Hello, everyone, and Welcome back for Episode 14 of Natural Prodcast . There’s been a lot going on, so I … never forced it on me, but we always had these scientific news magazines lying around at home. And I would just pick … takes about 10 years. Costs are in the range of $100 to $120 million to do that.  DAN: OK. So about the same amount …

… of secondary metabolism. Welcome back. This will be episode 12 of Natural Prodcast. And it’s our conversation with … Europe. So if there are any kind of dated references to the news, that’s why. But it was a really fun conversation. And I think you’ll enjoy it. So here it is, episode 12 with Nadine Ziemert. DAN UDWARY: Hey, Alison. ALISON …

… the Molecular Foundry, the project needs to be scoped for 12 months or less. We can help you scope that part of the proposal. Also, once awarded, users have 12 months before they need to activate their project. … end of an active proposal in order to continue access in 12-month increments.  At the JGI, a typical proposal is …

… as well as a unique opportunity to complete a California K-12 science or math teaching credential as an undergraduate …

… global diversity of alternative genetic codes (Science 2014), unearthing hundreds of thousands of new viral genomes … from the human gut microbiome. Nature Biotechnol.  39(1):105-114. Schulz F, et al. (2020) Giant virus diversity and … Reveal Thousands of Small, Novel Genes. Cell 178(5):1245-1259 Nayfach S, et al, (2019) New insights from …

… nice summer day in Seattle I think this was like 2013 or 2014. And antiSMASH — I know you’ve interviewed Marnix … access to the whole sigma catalog of precursors in their 12C form. You can feed those and look for incorporation in … would grow up our bacteria on 13C methane or methanol, feed 12C methionine, and we were able to pull out the quorum …

… Cas14 proteins discovered from JGI’s IMG/M database and … aa. They were initially identified by searching for Cas12d homologs across IMG/M’s assembled metagenomic data. It … out that some of these were shorter than the typical Cas12d proteins and were also found next to cas1 genes. Further …

… there a way to do that? DAN UDWARY: Well, so there’s good news and bad news on that. So one of the things that we’re trying to do … happening. And so we should have somewhere around 10, 11, 12 million BGCs in the database on the release, and that’s …

… from metagenomes. mSystems 9:e00888-24. https://doi.org/10.1128/msystems.00888-24 Coclet, C., Sorensen, P.O., Karaoz, U. … microbiome. Nat Commun 12, 3076. https://doi.org/10.1038/s41467-021-23402-7 Roux, S. and Emerson, J. (2022) Diversity … in Microbiology. 30, 11. https://doi.org/10.1016/j.tim.2022.05.003 Berg, M. et al. (2021) Host population diversity as a …