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… welcome back to Natural Prodcast, and this will be episode 11. This continues our little sprint on genome mining. In … talk and that now I can bring it to you. So enjoy, episode 11 of Natural Prodcast. Alison Takemura: Marnix, where are … some people went as far as saying, OK, we’re going to take 300 strains from our labs and measure them on their mass …

… development and adoption of classroom modules Currently 206 genomes have been selected with 11 published manuscripts published to-date Testimonials: … available datasets encompassing >150,000 isolate genomes, 230,000 metagenome-assembled genomes (MAGs), and 40,000+ …

… from metagenomes. mSystems 9:e00888-24. https://doi.org/10.1128/msystems.00888-24 Coclet, C., Sorensen, P.O., Karaoz, … of hypermutation in the global microbiome. Nat Commun 12, 3076. https://doi.org/10.1038/s41467-021-23402-7 Roux, S. … across Earth’s biomes. Nature Microbiology. 4, 1895–1906. https://doi.org/10.1038/s41564-019-0510-x Roux, S. et …

… that the JGI’s Annual User Meeting is coming up, August 30th through September 1st. Three days of great science, and … never forced it on me, but we always had these scientific news magazines lying around at home. And I would just pick … looking at emails and I just saw this pop up. And saw a C&E News job little box and I thought, wow, this would be …

… Great Salt Lake, which is a hypersaline terminal lake about 30 minutes away from campus. And we’re finding some really, … there a way to do that? DAN UDWARY: Well, so there’s good news and bad news on that. So one of the things that we’re … happening. And so we should have somewhere around 10, 11, 12 million BGCs in the database on the release, and …

… microbiomes. mSystems0:e01744-24. https://doi.org/10.1128/msystems.01744-24 Oliver, T., Varghese, N., Roux, S. et … metagenomic time-series from Lake Mendota. Sci Data 11 , 966 (2024). https://doi.org/10.1038/s41597-024-03826-8 … and archaea across Earth’s biomes. Nat Microbiol 4 , 1895–1906 (2019). https://doi.org/10.1038/s41564-019-0510-x …

… So I wanted to ask you also about – because you were in the news recently – TSRI has acquired the Pfizer strain … genome, the genome predicts they often can produce around 30 – more than 30 compounds. So, this was a complete surprise. So total, …

… this is Challis et al, Chemistry and Biology, 2000, 211-224, 7:3 And so, you can then make predictions about … we’re going to add another 87,000. So that’s, what, a 20%, 30% increase?  Dan insert: It’s a 21.75% increase. ALISON … Microbiomes” paper is here . Read the associated JGI news release here . Software we discussed, used for genome …

… for which JGI has not yet received samples as of Sep 30, 2021 are subject to a 2-year embargo to maintain the … Data from projects that received samples before Sep 30, 2021 and are ongoing are subject to the 2-year …

… on microbiomes they only talk about the bacteria. My god! 30% of our gut microbes are fungi. It’s really frustrating … And because the average fungal genome, I don’t know, is 30 megabases? Basidiomyetes might get to 50. Some of them go … there – some are private – that, you know, maybe you have 300 contigs. And so most fungi… Oh, the fungi vary in number …

… Europe. So if there are any kind of dated references to the news, that’s why. But it was a really fun conversation. And … all these 120 genomes, and each of them have– I don’t know– 30 gene clusters or so. So I think I spent two years only … this? NADINE ZIEMERT: It wasn’t that long ago, but maybe 2006, 2007, or something like that. And we actually found the …