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… been the main driver for secondary metabolism drug discovery. Because we always need new antibiotics. We need new … kind of works the same way for reasons that are still mostly unclear. And again, we talked about this in the earlier primers. In bacteria, at least, and in most fungi, biosynthetic gene clusters, which are the genes …

… a broad range of experimental work on plants for drug discovery in antibiotics, anticancer, and now COVID. We also … very excited today. Usually when we do these interviews, most of the people that I think we’ve talked to so far I … editor. And yeah, it just kind of came together in the most delightful and unexpected way. So I had to leave with …

… San Diego. San Diego, of course, is the “home turf” of my post-doctoral mentor, Brad Moore, who has joint appointments … to sit down and have a great chat with him.  I kind of lost count of how many times Brad used the words “fun” and … of marine natural products. And was at the university for over 40 years. There were four of us as kids in the family. …

… it. This is a conversation with Marc Chevrette. Marc is a postdoc in Jo Handelsman’s group at the University of … will be fun to be able to provide a semi-regular forum for postdocs and graduate students through Natural Prodcast, … what they were doing in these genomes and how they change over time. And yeah, I mean, that was let’s see, maybe 5,6,7 …

… having listened to the first part, you might be a little lost, and I’d suggest you go back and check the first episode … are still in – not an early stage. I think we can identify most secondary metabolism pathways now, but there’s still … a little bit more giving. DAN: Alright, so I think we’ve covered a little bit about why they’re important. But one of …

… of background. My name is Dan Udwary. I – as well as my co-host, Alison Takemura, whose voice you’ll hear in a minute – … Being a User Facility means that scientists from all over the world bring us big problems related to energy and … basically all living things. When your crazy Aunt is posting on Facebook about cinnamon or turmeric curing every …

… in the UK. And came across to the US for a couple of postdocs. One at Harvard Med School and the other at … to try and increase titer and rate and drive down the cost of producing riboflavin at scale.  DAN: Got it.  NIGEL … new strains and new process improvements and new ways to recover spinosyns. And so we had a high throughput screening …

… have a lot of listeners downloading this from countries all over the world – as many from outside the US as inside – and … structurally resolved in the 1980s, they were known as the most toxic molecules, and that human beings know, today, for … enediyne compounds by coupling it with antibodies.  DAN (post edit): Hey, Dan here with a quick interjection. Ben …

… but instead it’s two interviews in one. My new co-host, Jackie Winter, has been on a few episodes now, and I figured we were way overdue to give her a proper introduction and a chance to … been working on with my colleagues Drew Doering and Bryce Foster and too many others to name at JGI for the last two …

… integrate genomics with nanoscale science, accelerating discoveries and developing transformative bio-based technologies that address challenges in the sourcing, recovery, and utilization of critical minerals and materials. … sequencing—to JGI. Users are responsible for covering the costs of the experiment, sample collection, and shipping; JGI …

… are derived from isolates and single cells. This effort uncovers novel genes, protein families, and pathways, enhancing … metatranscriptomes. It provides rich data such as inferred host taxonomy, conjugation potential, antibiotic resistance … from genomes, metagenomes, and metatranscriptomes, with over 15 million viral genomes and fragments. …