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… collaborative user projects, the JGI’s Plant Program delves into the natural world’s potential to address global … to regulate Earth's carbon balance, to exploring the genetic basis of how plants have naturally adapted to varied … potential to inform strategies that improve agricultural yields and support ecosystem health. By integrating …

Program works to uncover the roles of small molecules in biological systems, linking them with genomic data to … metabolomics fuels the discovery  of novel metabolites, genes, and proteins. It also enables exploration of energy … JGI scientists are able to link metabolic activity with gene expression, providing deeper insights into functional …

… … DAN: You’re listening to the US Department of Energy Joint Genome Institute’s … what we’re calling a Primer. We wanted to try and give a general audience some of the basics of natural products … a tendency to be susceptible to a fungal infection of rye grain – a specific fungus, Claviceps purpurea, can infect …

… right. Welcome back to Natural Prodcast. I did it. I’m keeping to my schedule. This should be coming out on the first … Yeah. DAN: Yeah. Do you think your synthesis background influences a lot of what you do? BETSY PARKINSON: Oh, it … oftentimes will bind to receptors within biosynthetic gene clusters. Specifically, these are Tet repressors that …

… fantastic diversity of cell types and associated organisms, including fungal and bacterial symbionts, detrimental … single-cell and spatial transcriptomics barcode-based genetics (RB-TnSeq), and computational genomics to better … strains, whereby they can modulate host metabolism, gene expression and phenotype. We have recently identified …

… … Dan Udwary: You’re listening to the Department of Energy Joint Genome Institute’s … and BiG-SLiCE, and now the BiG-FAM database of biosynthetic gene cluster families. And he tells us about forthcoming … Island. And was working on a natural products/biosynthetic gene cluster database, and a tool for predicting natural …

The JGI’s Microbial Program focuses on using cutting-edge sequencing, annotation and analysis … energy and ecosystem management. The program aims to generate high-quality genomic datasets, particularly for … single cell approaches. This includes linking strain-level genetic variation to ecological niche adaptations.  Single …

… of Natural Prodcast. A little bit of a bonus episode, since I’m off schedule, but this is an important one that … bit more into fungi and learning the differences of all the genetic differences and then expanded on on that knowledge … mentoring. I enjoyed teaching and just helping the next generation of researchers in natural products and in other …

… for another episode of Natural Prodcast. Right now I’m working on this the afternoon of the day I’m due to release it, … and he has a project with the JGI to synthesize the genes for and explore the chemistry of quorum sensing … And Alison has done a really nice job of providing that general scientific audience whereas now I’m sitting here …

DAN UDWARY: You’re listening to the Department of Energy Joint Genome Institute’s … ALISON TAKEMURA: I know that it’s looking in the genome for genetic elements of interest, you know, something like … want to explain that to someone who doesn’t know much about genetics or anything else, science wise maybe, what genome …

The Metagenome Program uses advanced sequencing technologies to decode the genomes of microbes in their … along with their associated viruses and mobile genetic elements. Beyond exploring and characterizing … of viral, microbial, and microeukaryote genomes and mobile genetic elements, linked to custom interfaces and …

Miscanthus  sequence offers insights into benefits of polyploidy and perenniality. The … (polyploidy) and insights into the dynamics of gene expression as it grows back vigorously year after year … aims for bioenergy feedstock crops are increasing their yields and improving their abilities to adapt to extreme …