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… The Fungal & Algal Program explores the vast diversity of fungi … to unlock their potential for bioenergy, environmental sustainability, and bioproducts. By sequencing and analyzing the genomes of these organisms, the … The Fungal & Algal Program harnesses cutting-edge sequencing …

… The Fungal & Algal Program Advisory Committee is chartered by …

… Program works to uncover the roles of small molecules in biological systems, linking them with genomic data to enhance our understanding … metabolomics fuels the discovery  of novel metabolites, genes, and proteins. It also enables exploration of energy … JGI scientists are able to link metabolic activity with gene expression, providing deeper insights into functional …

… fantastic diversity of cell types and associated organisms, including fungal and bacterial symbionts, detrimental microbial … single-cell and spatial transcriptomics barcode-based genetics (RB-TnSeq), and computational genomics to better … strains, whereby they can modulate host metabolism, gene expression and phenotype. We have recently identified …

… The JGI has diverse capabilities in: DNA and RNA sequencing, Sample and library preparation, Biodesign and pathway engineering Mass spectrometry based metabolomics Below is a … to determine coverage of variants depends on project Fungal Minimal Draft Lower coverage short-read whole genome …

… Research Experience (CURE) that consists of coordinated hands-on experiments across fungal biology teaching labs. The purpose of the program is … species.  Students collect fungi, sterilize tissue, isolate genes and more. The metadata then goes into iNaturalist. …

… Machine learning methods were applied on sequenced fungal genomes to classify gene families. The Science As a proof of concept, … The work conducted by the U.S. Department of Energy Joint Genome Institute, a DOE Office of Science User Facility, … Dothideomycetes genomes were conducted as part of the 1000 Fungal Genomes Project supported by the JGI Community …

… It was unpublished at that point. But people would push out gene clusters maybe once a month at most. Maybe twice a … colors. I mean, where else in nature– and they’re not fungal. Where else nature can you go see colonies of … if you want– if you really want to, you can do heterologous expression. You can do homologous expression techniques and …

… and BiG-SLiCE, and now the BiG-FAM database of biosynthetic gene cluster families. And he tells us about forthcoming … was a proposal on synthetic biology of engineering gene expression in bacteria – however, the professor was actually … are protecting the plants against pathogens. So usually fungal or oomycete pathogens. In this case they worked on a …

… collaborative user projects, the JGI’s Plant Program delves into the natural world’s potential to address global challenges by exploring plants’ role in capturing carbon, detoxifying soils, interacting with … to regulate Earth's carbon balance, to exploring the genetic basis of how plants have naturally adapted to varied …

… growth, provide critical advantages to the organisms producing them, and are often involved in defense, nutrient acquisition and communication. Studying … conditions, with only a small portion of the biosynthetic gene clusters (BGCs) being expressed. The program works to …

… DAN: You’re listening to the US Department of Energy Joint Genome Institute’s … episode is our conversation with Nancy Keller, a fantastic fungal natural products researcher from the University of … After I got my undergraduate degree, which was in general biology, I joined the Peace Corps. And when I was …