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… solutions to current problems facing humanity. A major focus are biofuel feedstock species and plant-microbe … to regulate Earth's carbon balance, to exploring the genetic basis of how plants have naturally adapted to varied … Centers. The  Plant Gene Atlas initiative develops gene expression catalogs across JGI Plant Flagship …

The Fungal & Algal Program explores the vast diversity of fungi and algae to unlock their potential for bioenergy, … on large-scale sequencing efforts that survey the vast phylogenetic and ecological diversity of fungi and algae, … genes conserved across the fungal tree of life or its major branches for users to characterize and propagate …

… conditions, with only a small portion of the biosynthetic gene clusters (BGCs) being expressed. The program works to … pathway analysis, optimization of cell- and cell free-based expression platforms, tools and data for deciphering regulatory networks, and refining experimental approaches to …

… my undergraduate in microbiology and then PhD in microbial genetics in the UK. And came across to the US for a couple … I can say.  DAN: Sure, sure.  NIGEL MOUNCEY: So we had two major natural products projects that we had in my group … explore the regulation of biosynthetic gene cluster expression in organisms. And that’s led by Hiroshi Otani …

… oftentimes will bind to receptors within biosynthetic gene clusters. Specifically, these are Tet repressors that … spread since we're just doing bioinformatic searches. The majority of them are actinos, but not all of them are. … So that's been a really exciting part of this journey, is finding these enzymes that are capable of making those …

… metabolomics fuels the discovery  of novel metabolites, genes, and proteins. It also enables exploration of energy … biological and environmental samples — including microbes, fungi, plants and soils. Through a combination of … scientists are able to link metabolic activity with gene expression, providing deeper insights into functional …

… great example of probing fungi for natural products and finding new things. And so, really happy to have you here. … After I got my undergraduate degree, which was in general biology, I joined the Peace Corps. And when I was … to grad school in microbiology. And certainly, I mean, the majority of it was focused on bacteria. And this was at MIT. …

It was unpublished at that point. But people would push out gene clusters maybe once a month at most. Maybe twice a … point. So– BRIAN BACHMANN: So that was why– that’s a major focus of the group. Now, the cave organisms are there … BACHMANN: Exactly, and you can solve your problems by just finding a different producer. I mean, Bill Metcalf at UIUC …

… and he has a project with the JGI to synthesize the genes for and explore the chemistry of quorum sensing … of these or any organisms. So developing good heterologous expression hosts like maybe in many fields now like in … by one of these small molecules, how would you go about finding what that small molecule is? AARON PURI: Yeah. So …

… and BiG-SLiCE, and now the BiG-FAM database of biosynthetic gene cluster families. And he tells us about forthcoming … was a proposal on synthetic biology of engineering gene expression in bacteria – however, the professor was actually … this field either. So they used antiSMASH and they report findings using antiSMASH. And it’s actually quite a …

… natural chemical compounds that you find in plants, fungi and bacteria, basically all living things. When your … what we’re calling a Primer. We wanted to try and give a general audience some of the basics of natural products … was maybe natural products that would cause some, you know, major historical events and craziness in human history.  …

… from any institution type and at any career stage. Generally, most users are able to work with Berkeley Lab.  … other genomic resource needs. … Scientific merit is the major criteria used in evaluating proposals; however, the … your samples, but do not serve as a comprehensive list of regulatory requirements. The user is responsible for …