Eddy Rubin

Edward Rubin MD, PhD Director, DOE Joint Genome Institute

Edward Rubin MD, PhD
Director, DOE Joint Genome Institute

  • BA in Physics, University of California, San Diego, CA
  • MD, University of Rochester Medical Center, Rochester, NY
  • PhD, Biophysics, University of Rochester, Rochester, NY

Awards and Service

Dr. Rubin received an Honorary Doctorate of Science Degree from Middlebury College, the University of Rochester Dean’s Award, the Netherlands Heart Association Declaration of Esteem, the American Heart Association Established Investigator Award and has been inducted into the American Society of Clinical Investigation. He is a member of the Jackson Laboratory Board of Trustees, the Genome Canada Board of Directors, Chair of the Scientific Advisory Board for the Genome Institute of Singapore as well as serving on the scientific advisory boards of several additional biotechnology and research institutions. He has served as a member of the Board of Reviewing Editors for the Journal Science and the editorial boards of several other journals.


Edward M. “Eddy” Rubin is an internationally-known geneticist and medical researcher at the Lawrence Berkeley National Laboratory in Berkeley, California, where he became head of the Genomic Sciences Department in 1998. In 2002 he assumed the directorship of the DOE Joint Genome Institute (JGI) to lead the JGI’s involvement in the Human Genome Project (HGP). Under his leadership, the JGI completed the sequencing and analysis of human chromosomes 5, 16 and 19 (~13% of the human genome). After completion of the HGP, Dr. Rubin has led the reorientation of the JGI as a next-generation genome science center, applying genomics to studies related to bioenergy and the environment, sequencing and analyzing the genetic code of thousands of plants, fungi and microbes.

Dr. Rubin’s research has involved the development and application of computational and biological approaches for studying genomes. His early work focused on decoding the human genome. He then championed its functional exploration, harnessing sequence comparisons between species for the discovery of genes and non-coding sequences of pivotal evolutionary and biomedical importance. Other related work included sequencing and analysis of regions of the genomes of extinct cave bears and Neanderthals. More recently, he has expanded the frontiers of the new science of metagenomics, deriving important insights from his investigations of microbial communities inhabiting environments ranging from gutless ocean-dwelling worms to cow rumen. Dr. Rubin has published over 250 peer-reviewed manuscripts with more than 35 of them appearing in the journals Science and Nature.

Selected Publications (from >200)

  1. Woyke, T and Rubin, E. Searching for new branches on the tree of life. Science 2014 346 (6210): 698-699 Summary. Free Full Text. Free PDF.
  2. Ivanova N et al. Stop codon reassignments in the wild. Science 2014 344 (6186): 909-913                   Free Full Text  Free PDF
  3. Rinke C et al.  Insights into the phylogeny and coding potential of microbial dark matter. Nature. 2013 499, 431–437
  4. Hess M et al. Metagenomic discovery of biomass-degrading genes and genomes from cow rumen. Science. 2011 28;331(6016):463-7.
  5. Rubin EM. Genomics of cellulosic biofuels. Nature. 2008 454(7206):841-5.
  6. Sorek R et al. Genome-wide experimental determination of barriers to horizontal gene transfer. Science. 2007;318(5855):1449-52.
  7. Noonan JP et al. Sequencing and analysis of Neanderthal genomic DNA. Science. 2006 Nov 17;314(5802):1113-8.
  8. Tringe SG et al. Comparative metagenomics of microbial communities. Science. 2005; 22;308(5721):554-7.

List of Dr. Rubin’s Publications on PubMed

Pre- and Postdoctoral Trainees of Participating Faculty for the Previous Ten Years