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… getting them out to you all. But for now, here is episode 10 of Natural Prodcast, the primer on genome mining. Hey, … Microbiomes. Nature  Biotechnology . 2020 Nov 9. doi: 10.1038/s41587-020-0718-6) DAN UDWARY: Yeah, I think that might … Microbiomes” paper is here . Read the associated JGI news release here . Software we discussed, used for genome …

… metabolism. Hey everybody, this is Dan with episode 13 of National Prodcast. This continues our little section … a bit embarrassed that we recorded this conversation about 10 months ago. I was pretty green at the time and had some … to my daughters– what did they think would be important in 100 years. Would natural products be important for …

… And you have these different types of particulate like 2.5, 10 PPMs and just the size of the particle and how far they … there a way to do that? DAN UDWARY: Well, so there’s good news and bad news on that. So one of the things that we’re …

… like a nice summer day in Seattle I think this was like 2013 or 2014. And antiSMASH — I know you’ve interviewed Marnix … acyl-homoserine lactone signal . mBio. 2023 Aug 31;14(4):e0101023. doi: 10.1128/mbio.01010-23. Publication: Cummings …

… So they’re in the picomolar range. ALISON: Picomole… is [10 to the] minus twelve, right? BEN: Yeah, yeah. Well, we … So I wanted to ask you also about – because you were in the news recently – TSRI has acquired the Pfizer strain … look at several natural product enediyne structures, Ben’s 2015 paper on genome mining for enediynes is one of my …

… never forced it on me, but we always had these scientific news magazines lying around at home. And I would just pick … had a high throughput screening platform where we’d look at 10,000, 15,000, 20,000 mutants a week. We started doing a … Metabolites Science Program . Since his arrival in 2017, Nigel has led a vision for the JGI that sees secondary …

… pairs. It was not linear, like Streptomyces , but circular. 10% of the genome encoded natural product pathways. Dan: … has been a lot of fun for us in recent years. Started in 2015, when two things happened. One, a new graduate student … still with us? Brad:  Unfortunately, not. We lost him about 13 years ago. So, I wish he was still with us because I know …

… convince those people of that fact, however, a long time, 10 years! ALISON TAKEMURA: Wow. It’s all happened so fast. I … of the molecules in ecology. And that took another 10 years at least. But I had several students. And I worked … cancer. And that means that you have to provide up to maybe 100 grams of the natural product. And that was, for us, very …