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… communication. Studying how these compounds are biosynthesized and their roles in the environment, can unlock new … of cell-free based expression platforms: Only 10-20% of BGCs are expressed under standard laboratory … This is based on extensive computational analyses of BGC size and complexity, BGC sequence composition, metabolic …

… readiness to begin work, checking such factors as genome size, polymorphism level, sample quality and availability, …

… tackle more functional questions. For example, we can synthesize a gene and then figure out what it might be doing … We don’t want to get a proposal that’s just asking for 20 microbial genomes. That is not a good fit for our annual … and expertise to do the bioinformatics and to synthesize these results into publication? So there’s this really …

Yeah, that’s right. We were postdocs together in the mid 2000s, I guess. You were working for Brad Moore. I was … cluster. So either both of those pools have to increase in size dramatically, or there has to be a significant … basement, and it was run by a dedicated team. It was the size of a hotel room, and it was always broken. DAN:  I …

Program leads to discuss available options. Note: In 2021, we conducted an extensive internal product audit to … (median/75th percentile*) DNA Synthesis Constructs <5kb in size Single gene or multiple small genes assembled to less … verified clone 102/NA DNA Synthesis Constructs 5-10kb in size Single gene or multiple small genes assembled totaling …

… in this hypersaline environment, which can range from 8% to 28% salinity. We have toxic metals, so these concentrations … types of particulate like 2.5, 10 PPMs and just the size of the particle and how far they can actually travel. … new supercomputer called Dori. I think it’s a moderately sized machine. It’s not super huge, but it’s allowed us to …

… 10 to the negative 9th. Picomolar, 10 to the negative 12th. DAN: Yeah. So very-- BETSY PARKINSON: Very, very-- … can activate these, utilizing some of these already synthesized molecules. DAN: OK. These receptors are coming from … or you can use a nucleophilic sidechain to make other ring sizes. When we were starting off this project though, we …