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… welcome back to Natural Prodcast, and this will be episode 11. This continues our little sprint on genome mining. In … tell a quick story. Looking back, the year was probably 2010, 2011, I was a, uh- actually, I’ve got the t-shirt on … microbiome field, many people had just been looking at like 16S taxonomic profiles of these communities looking at who …

… getting them out to you all. But for now, here is episode 10 of Natural Prodcast, the primer on genome mining. Hey, … this is Challis et al, Chemistry and Biology, 2000, 211-224, 7:3 And so, you can then make predictions about … Microbiomes. Nature  Biotechnology . 2020 Nov 9. doi: 10.1038/s41587-020-0718-6) DAN UDWARY: Yeah, I think that …

… so there are– I hesitate to make a guess but maybe 50 to 100 different strains and they are in individual tubules.  … in the field, these glacial bacteria grow slow and it’s not 100% clear that we know what their biological activities … call this the needle in the Haystack. Because if we have 10,000 features which one do we look at because we are a …

… And you have these different types of particulate like 2.5, 10 PPMs and just the size of the particle and how far they … there a way to do that? DAN UDWARY: Well, so there’s good news and bad news on that. So one of the things that we’re …

… modules Currently 206 genomes have been selected with 11 published manuscripts published to-date Testimonials: … Resour Announc 0:e00891-25. https://doi.org/10.1128/mra.00891-25 . B. Christenson, I. Nouioui, C. Daum, M. … 40 hours a week outside of school . They can't commit 8, 10, 20 hours a week in the research lab, but they can commit …

… microbiomes. mSystems0:e01744-24. https://doi.org/10.1128/msystems.01744-24 Oliver, T., Varghese, N., Roux, S. et … Lake Mendota. Sci Data 11 , 966 (2024). https://doi.org/10.1038/s41597-024-03826-8 Nayfach, S., Roux, S., Seshadri, …

… So they’re in the picomolar range. ALISON: Picomole… is [10 to the] minus twelve, right? BEN: Yeah, yeah. Well, we … So I wanted to ask you also about – because you were in the news recently – TSRI has acquired the Pfizer strain …

… convince those people of that fact, however, a long time, 10 years! ALISON TAKEMURA: Wow. It’s all happened so fast. I … of the molecules in ecology. And that took another 10 years at least. But I had several students. And I worked … course using modern phylogenetic tools measuring genes, the 16S gene, and comparing it with everything that’s known. So …

… first started out the natural product community was almost 100% bacterial. Only people working in mycotoxins worked … do you check if they’re there? Like we always talk about 16S for bacteria, but we don’t talk about it so easily with … mostly coming out of China and India, very cheap for $100-$200. But you have so many contigs. This is a problem …

… from metagenomes. mSystems 9:e00888-24. https://doi.org/10.1128/msystems.00888-24 Coclet, C., Sorensen, P.O., Karaoz, … ecosystem. Microbiome 11, 237. https://doi.org/10.1186/s40168-023-01666-z Neri U., Wolf, Y., Roux S., Camargo A.P., et …