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… want to go back and listen to the first two parts ( part 1 is here and part 2 is here ) so you understand what’s … 3 of the Primer! — DAN: So, you know, in the in the 50s 60s 70s, most of the exploration of this is done by what’s … the number was. But I want to say it was like less than 10. Since, you know, a recent decade.  DAN: I’m sure that’s …

… welcome back to Natural Prodcast, and this will be episode 11. This continues our little sprint on genome mining. In … for a while. Version 5 has been around for a bit. Version 6 is on the way, I hear? You just said. So antiSMASH is … field, many people had just been looking at like 16S taxonomic profiles of these communities looking at who is …

… at the University of Hawaii and moved there in the early ’60s from Berkeley to work on this new budding field of … pairs. It was not linear, like Streptomyces , but circular. 10% of the genome encoded natural product pathways. Dan: … vehicles. Brad: You did not! Alison: I did, like 2016, I think. Yes, it was just so funny to hear how they’re …

… And I set that up. And we finally got that to work 10 years later. But in the meantime there, we had people … And I thought, well, I know that we can do this. So in 2006 was when I started our cave-based natural product … of thing. But it’s a lot of work. So to me, to us, about 6 years ago, we thought the big gap in genome mining is not …

… like a nice summer day in Seattle I think this was like 2013 or 2014. And antiSMASH — I know you’ve interviewed Marnix … learn as much about it as possible starting with we picked 183 of them. And we sent that list to the Joint Genome … Stable Isotopic Labeling . ACS Chem Biol. 2021 Aug 20;16(8):1332-1338. doi: 10.1021/acschembio.1c00329. …

… like plasmids, the picture is far from complete.  In 2021 , scientists at St. Jude Children’s Research Hospital … of Energy Joint Genome Institute (https:// ror.org/04xm1d337), a DOE Office of Science User Facility, is supported … Office of Science of the U.S. Department of Energy [DE-AC02-05CH11231]. Dr. Charles Gawad has been supported for this …