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… approved proposal – including the submission of samples for sequencing, or the submission of sequencing data for synthesis – the DOE requires that all …

… of critical minerals and materials. For accepted proposals, sequencing, synthesis, metabolomics and analysis will be …

… which was a very early genome mining company, back when DNA sequencing of natural product pathways was hard and … polyketide synthase and then P3. We still don’t know why 20 years later. JACKIE WINTER: It’s pretty amazing, … it was a big deal. And you really had– I mean, the whole sequencing endeavor, had a cost, how much blood, sweat, and …

… to DOE mission is appropriate. For accepted proposals, sequencing, synthesis, metabolomics and analysis will be …

… the Broad that was looking to develop new methods for DNA sequencing of microbes. And what kept breaking our methods … So you were saying, Mark, how the DNA that was breaking the sequencing from really being functional was these secondary metabolite pathways. So why was that? What is it about secondary metabolite pathways …

… The genes are pretty much 100% identical. We don't know why one is expressed over the other. As far as whether we're … technology.] BETSY PARKINSON: OK. DNA affinity purification sequencing. And so the way this essentially works is you … at the college level. So-- DAN: Yeah, for sure. And JGI is sequencing quite a few of the things that end up-- BETSY …

… A Letter of Intent is required. For accepted proposals, sequencing, synthesis, metabolomics and analysis will be …

… anyone to freely investigate the genes of more than 100 algae. The Science Interested in the genomes of algae? You now have one place where you can browse the … and visualize supporting experimental data. The Impact Algae are important organisms. They play key roles in global …

… and the 90s. And so we started to be able to explore DNA sequencing and actually get to the DNA sequence – sequences … Something that’s you know …  ALISON: Central! DAN: That’s why they called it that! But for, maybe, people who are less … We have a lot more data. Obviously, there’s been a lot of sequencing going on, especially at the JGI and in other …

… your interest in getting into natural products. DAN: Why are you here at SIMB? AARON PURI: Yeah. Thanks Jackie. … JGI and this was before they were integrated. So I thought, why not feed it in there. And I went to group meeting and … AARON PURI: Yeah. No, you’re exactly right. So you can see why these are tightly regulated. DAN: For sure. For sure. …

… the JGI sequences around 35,000 samples — from plants, algae, bacteria, archaea, fungi, viruses — to support … samples in from afar, without ever hearing much about the sequencing lab. So today, Chris Daum walks through the JGI’s sequencing pipeline, where there are freezers with names — …