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Mining Metagenomes for Cas Proteins
… Cas14 proteins discovered from JGI’s IMG/M database and … report the identification of active Cas enzymes – dubbed Cas14 – that target ssDNA. In contrast, the seminal Cas9 … while Burstein is now at Tel Aviv University. The Cas14 proteins are ~400–700 amino acids (aa) in size, half that …
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JGI@25: Tracking & Subduing the Plague of California’s Oak Woodlands
… relative of SOD is P. infestans , responsible for the mid-19th century Irish potato famine.   Shortly before the … University, was released to the public in a highly-cited 2006 publication in the journal Science . This provided a … 1;313(5791):1261-6. doi: 10.1126/science.1128796 Science News of the Day: Stokstad E. Genetics. Genomes highlight …
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Natural Prodcast Episode 19: Bill Fenical
… that there was almost nothing. Now, this is back in the 1970s. So, I thought to myself, maybe I can use my … with the National Cancer Institute who had a panel of 60 different cancer cell lines. And we would send them these … using modern phylogenetic tools measuring genes, the 16S gene, and comparing it with everything that’s known. So …
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Secondary Metabolites Program
… Development of cell-free based expression platforms: Only 10-20% of BGCs are expressed under standard laboratory …
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Examples: Successful LOIs & Submissions
… CSP Large Scale Proposal #1 … CSP Large-Scale LOI #1 … FICUS Example #1 …
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Data Ecosystem
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Tanja Woyke Elected to American Academy of Microbiology
… American Academy of Microbiology (AAM) ! She is among the 68 new Fellows in the Class of 2020, selected from 118 … the AAM Fellows in this cohort. Go here for the full AAM news release. Woyke is also one of the organizers for the …
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Events
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JGI Portals
… metagenomes, and metatranscriptomes. It features over 15 million viral genomes and fragments, enriched with … Portal was replaced with the Data Portal and sunset in 2026. The Genome Portal was designed to provide unified access … and analytical tools for all JGI sequencing projects. In 2021, the JGI launched the Data Portal to eventually replace …
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Microbiome Data Science Team
… global diversity of alternative genetic codes (Science 2014), unearthing hundreds of thousands of new viral genomes and their predicted hosts (Nature 2016, Science 2017, Nature Microbiology 2018), discovery of … dark matter through global metagenomics. Nature . 622(7983):594-602. Camargo AP. et al. (2023) Identification …
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New Vision, New Mission, New Plan: The JGI’s Next Five Years
… for the next five years. It also includes more than 130 implementation milestones to help track and drive … path, has previously proven successful; in the 2018-2023 five-year strategic plan, the JGI accomplished 90% …
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Engagement Webinar: What Can You Do With An Approved CSP Functional Genomics Call Proposal?
… Synthesis Science Head] Yasuo [Yoshikuni] gave back in 2016.” Alper’s first approved JGI proposal came through the … development and its applications. “I moved to UC Davis in 2014,” recalled Philipp Zerbe of the University of California, …
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