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Mining Metagenomes for Cas Proteins
… Cas14 proteins discovered from JGI’s IMG/M database and … report the identification of active Cas enzymes – dubbed Cas14 – that target ssDNA. In contrast, the seminal Cas9 … while Burstein is now at Tel Aviv University. The Cas14 proteins are ~400–700 amino acids (aa) in size, half that …
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JGI@25: Tracking & Subduing the Plague of California’s Oak Woodlands
… relative of SOD is P. infestans , responsible for the mid-19th century Irish potato famine.   Shortly before the … All told, the disease has accounted for upwards of $30 billion in losses , including the death of tens of … 1;313(5791):1261-6. doi: 10.1126/science.1128796 Science News of the Day: Stokstad E. Genetics. Genomes highlight …
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Natural Prodcast Episode 19: Bill Fenical
… that there was almost nothing. Now, this is back in the 1970s. So, I thought to myself, maybe I can use my … underwater. But thankfully that worked out. And I spent 30, 40 years diving all over the world and bringing samples … chemistry. And I’ve studied microbiology for about 25, 30 years. And I can actually go give a talk at ASM [The …
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Secondary Metabolites Program
… Development of cell-free based expression platforms: Only 10-20% of BGCs are expressed under standard laboratory …
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Examples: Successful LOIs & Submissions
… CSP Large Scale Proposal #1 … CSP Large-Scale LOI #1 … FICUS Example #1 …
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Data Ecosystem
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Tanja Woyke Elected to American Academy of Microbiology
… As a result, the giant virus protein space grew from 123,000 to over 900,000 proteins, and virus diversity in this … the AAM Fellows in this cohort. Go here for the full AAM news release. Woyke is also one of the organizers for the …
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Events
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JGI Portals
… metagenomes, and metatranscriptomes. It features over 15 million viral genomes and fragments, enriched with … and analytical tools for all JGI sequencing projects. In 2021, the JGI launched the Data Portal to eventually replace …
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Microbiome Data Science Team
… global diversity of alternative genetic codes (Science 2014), unearthing hundreds of thousands of new viral genomes and their predicted hosts (Nature 2016, Science 2017, Nature Microbiology 2018), discovery of new genes with … Pavlopoulos GA et al. (2023) Unraveling the functional dark matter through global …
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New Vision, New Mission, New Plan: The JGI’s Next Five Years
… for the next five years. It also includes more than 130 implementation milestones to help track and drive … path, has previously proven successful; in the 2018-2023 five-year strategic plan, the JGI accomplished 90% …
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Engagement Webinar: What Can You Do With An Approved CSP Functional Genomics Call Proposal?
… call is open year-round, but proposals submitted by July 30 will be included in the next review. “So webinars like … Synthesis Science Head] Yasuo [Yoshikuni] gave back in 2016.” Alper’s first approved JGI proposal came through the … development and its applications. “I moved to UC Davis in 2014,” recalled Philipp Zerbe of the University of California, …
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