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… went on to work at a groundbreaking company in the early 2000s called Ecopia, which was a very early genome mining … And I thought, well, I know that we can do this. So in 2006 was when I started our cave-based natural product … of thing. But it’s a lot of work. So to me, to us, about 6 years ago, we thought the big gap in genome mining is not …

… recruit new talent for biosciences.  Adopt-a-Genome has: ~20 faculty from institutions across the country Efforts in … development and adoption of classroom modules Currently 206 genomes have been selected with 11 published manuscripts … Laar. Draft Genome Sequence of Muricoccus roseus DSM 14916T, isolated from a children’s care center in …

… found in Yu et al, APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 2004, 1253–1262, 70:3 ALISON TAKEMURA: And so did you succeed in finding … Nature  Biotechnology . 2020 Nov 9. doi: 10.1038/s41587-020-0718-6) DAN UDWARY: Yeah, I think that might be a good … Microbiomes” paper is here . Read the associated JGI news release here . Software we discussed, used for genome …

… list available at Google Scholar. Dutkiewicz, Z. et al (2025) “ Proposal of Patescibacterium danicum gen. nov., sp. … ISME Communications , Volume 5 Issue 1. Wittmers, F. et al (2024) “ Non-photosynthetic lineages sibling to Cyanobacteria … genomes with GVClass. ”  npj Viruses, Volume 2 Article 60. …

… never forced it on me, but we always had these scientific news magazines lying around at home. And I would just pick … screening platform where we’d look at 10,000, 15,000, 20,000 mutants a week. We started doing a whole bunch of … Metabolites Science Program . Since his arrival in 2017, Nigel has led a vision for the JGI that sees secondary …

… Europe. So if there are any kind of dated references to the news, that’s why. But it was a really fun conversation. And … all these very, very related genomes, right – on their 16S level, they’re almost identical! But seeing all these …

… So I wanted to ask you also about – because you were in the news recently – TSRI has acquired the Pfizer strain … these natural products. So this gives you approximately a 6% successful drug discovery rate.   And this is 100 times … look at several natural product enediyne structures, Ben’s 2015 paper on genome mining for enediynes is one of my …

… reminds me almost working with Bill back in the ’50s and ’60s of the golden age of antibiotic discoveries. Everything … there a way to do that? DAN UDWARY: Well, so there’s good news and bad news on that. So one of the things that we’re … Metabolites Collaboratory SMC Workshop Materials from the 2023 JGI Annual Meeting Using the SMC Website API Endpoints …

… Myco-Ed has:  ~50 lineages selected for sequencing 16 genomes released 20 members from 15 institutions 300+ students 800+ …

… FY2025 Spending Profile The JGI is funded primarily by the DOE …

… seems hard to believe in retrospect. BILL FENICAL: Well, in 2021, absolutely hard to believe. But when you go way back, … with the National Cancer Institute who had a panel of 60 different cancer cell lines. And we would send them these … using modern phylogenetic tools measuring genes, the 16S gene, and comparing it with everything that’s known. So …